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Current Bibliographies in Medicine 98-3


Zinc and Health


January 1990 through June 1998

3619 Citations

Prepared by
Adam Glazer, M.S.L.S., National Library of Medicine
Kristine M. Scannell, M.S.L.S., National Library of Medicine
Rebecca B. Costello, Ph.D.,Office of Dietary Supplements, National Institutes of Health
Terri J. Krakower, Ph.D.,Office of Dietary Supplements, National Institutes of Health
Bernadette M. Marriott, Ph.D. Office of Dietary Supplements, National Institutes of Health

1998 October

U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Institutes of Health

National Library of Medicine
Reference Section
8600 Rockville Pike
Bethesda, Maryland 20894



Series Note

Each bibliography in the Current Bibliographies in Medicine (CBM) series covers a distinct subject area of biomedicine and is intended to fulfill a current awareness function. Citations are usually derived from searching a variety of online databases. NLM databases utilized include MEDLINE®, AVLINE®, BIOETHICSLINE®, CANCERLIT®, CATLINE®, HEALTHSTARtm, POPLINEtm, and TOXLINE®. The only criterion for the inclusion of a particular published work is its relevance to the topic being presented; the format, ownership, or location of the material is not considered.

Other publications in the Current Bibliographies in Medicine series are available at no cost to anyone with Internet access through the Library's World Wide Web site at http://www.nlm.nih.gov/pubs/resources.html.

Comments and suggestions on this series may be addressed to:

Karen Patrias, Editor
Current Bibliographies in Medicine
Reference Section
National Library of Medicine
Bethesda, MD 20894
Phone: 301-496-6097
Fax: 301-402-1384
mailto:ref@nlm.nih.gov

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Table of Contents

Series Note

Introduction

Sample Citations

Bibliography:

OVERVIEW OF ZINC NUTRITION

ZINC AND THE GASTROINTESTINAL TRACT

ZINC AND THE IMMUNE SYSTEM, ANTIOXIDANT, AND DEFENSE FUNCTIONS

ZINC AND CELLULAR MECHANISMS

ZINC AND THE CENTRAL NERVOUS SYSTEM

ZINC IN GROWTH AND SPECIFIC DISEASE ENTITIES

CURRENT METHODS UTILIZED FOR ASSESSING ZINC

Return to title page

Introduction

ZINC AND HEALTH

This bibliography was prepared in support of the National Institutes of Health Workshop and Conference on Zinc and Health, sponsored by the Office of Dietary Supplements, held in Bethesda, Maryland, November 4-6, 1998. Co-sponsors of the workshop included the American Dietetic Association, the American Society for Clinical Nutrition, six offices and institutes at NIH*, the Department of Defense, and the Centers for Disease Control and Prevention. The bibliography provides a list of journal articles and books that contain information in the field of zinc research and health, integrating both a cellular and clinical perspective. It has been divided into seven sections to include (1) an overview of zinc nutrition; (2) zinc and the gastrointestinal tract; (3) zinc and the immune system; antioxidant and defense functions of zinc; (4) zinc and cellular mechanisms; (5) zinc and the central nervous system; (6) zinc in growth and specific disease entities; and (7) current methods utilized for assessing zinc.

The first section provides an overview of zinc nutrition and contains studies defining the requirements, physiology, and metabolism of zinc, and studies that delineate the role of zinc in the human body. Articles reviewing many of the classic epidemiological studies evaluating zinc status in different population groups are also included in this first section. In the second section that focuses on absorption, bioavailability, and excretion of zinc in the GI tract, an overview is presented in tandem with studies describing the integrative aspects of zinc transporter proteins and the regulation of intestinal gene expression by dietary zinc. The third section on the immune system, antioxidant and defense functions of zinc, provides an in-depth review of research in the areas of zinc-altered immune function and cytokine production, and the role of zinc metallothionein in oxidative reactions. Also included in this section are reviews on the mechanisms surrounding the role of zinc in the regulation of apoptosis and gene-directed cell death. The fourth section contains studies on the basic cellular chemistry of zinc and the cellular mechanisms regulated by zinc. Included in this section is the role of zinc in plasma and membrane function, teratogenesis and differentiation, and metalloenzymes most notably zinc finger proteins. The fifth section surveys the literature to elucidate the importance of zinc in the central nervous system. Topics covered include zinc transport and synaptic signaling, altered cognitive function, Alzheimer's Disease, and B-Amyloid induced zinc deficiency, as well as the neurobiology of zinc-influenced eating behavior. Section six on zinc in growth and specific disease entities reviews the clinical consequences of zinc deficiency as well as zinc supplementation and results from zinc intervention trials. The role of zinc in other clinical diseases of interest include diabetes, immune disorders and HIV, and zinc and the common cold. Lastly, section seven on research methodology provides reviews that report and establish new methods for the measurement and assessment of zinc status utilizing techniques from basic laboratory research, in vitro and in vivo methods, and clinical laboratory assessment methods.

Because the literature is extensive, this bibliography is necessarily selective. Preference was given to references to original journal articles, technical reports, and books identified from January 1990 to June 1998. The journal articles and other publications have been limited to those in English or those which have English abstracts that deal with basic science, animals models, and human subjects. References may be included in more than one subject category.

The compilers wish to acknowledge the valuable contribution of Phyllis Levine from NLM for her assistance.

*Fogarty International Center, National Institute of Dental Research, National Institute on Drug Abuse, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of General Medical Sciences, and the Office of Research on Women's Health

Any reproduction of this bibliography, in whole or in part, must include all credits. If you wish to cite this bibliography, the correct format is:
Glazer, Adam; Scannell, Kristine M.; Costello, Rebecca B.; Krakower, Terri J.; Marriott, Bernadette M., compilers. Zinc and health [bibliography on the Internet]. Bethesda (MD): National Library of Medicine; 1998 Oct. (Current bibliographies in medicine; no. 98-3). 3619 citations from January 1990 through June 1998. Available from: http://www.nlm.nih.gov/pubs/resources.html

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Sample Citations

Citations are formatted according to the rules established for Index Medicus ®. Sample journal and monograph citations appear below. For journal articles written in a foreign language, the English translation of the title is placed in brackets; for monographs, the title is given in the original language. In both cases the language of publication is shown by a three letter abbreviation appearing at the end of the citation.

Journal Article:

Example:
Marshall S. Zinc gluconate and the common cold. Review of randomized controlled trials. Can Fam Physician 1998 May;44:1037-42.

Order, with separating punctuation:
Authors. Article Title. Abbreviated Journal Title Date;Volume(Issue):Pages.

Monograph:

Example:
Prasad AS, Shiva A. Biochemistry of zinc. New York: Plenum Press; 1993. 303 p.

Order, with separating punctuation:
Authors/Editors. Title. Place of Publication: Publisher; Date. Total No. of Pages.

For details of the formats used for references, see the following publication:
Patrias, Karen. National Library of Medicine recommended formats for bibliographic citation. Bethesda (MD): The Library; 1991 Apr. Available from: NTIS, Springfield, VA; PB91-182030.

Return to title page | Return to table of contents

OVERVIEW OF ZINC NUTRITION

Essential trace elements and thyroid hormones. Lancet 1992;339(8809):1575-6.

FDA issues proposals on nutritional-product health claims. Am J Hosp Pharm 1994;51(4):448.

Importance of zinc for hormone binding and signal transduction: limiting mechanisms in zinc deficiency? Nutr Rev 1991 Dec;49(12):369-70.

Zinc and the regulation of vitamin B6 metabolism. Nutr Rev 1990 Jun;48(6):255-8.

Aballay A, Arenas NG, Quest AF, Mayorga LS. A factor with a zinc- and phorbol ester-binding domain is necessary for endosome fusion. Exp Cell Res 1997 Aug 25;235(1):28-34.

Abbott RA, Cox M, Markus H, Tomkins A. Diet, body size and micronutrient status in Parkinson's disease. Eur J Clin Nutr 1992 Dec;46 (12):879-84.

Abdallah SM, Samman S. The effect of increasing dietary zinc on the activity of superoxide dismutase and zinc concentration in erythrocytes of healthy female subjects. Eur J Clin Nutr 1993 May;47(5):327-32.

Abdel-Mageed AB, Oehme FW. A review of the biochemical roles, toxicity and interactions of zinc, copper and iron: I. Zinc. Vet Hum Toxicol 1990 Feb ;32(1):34-9.

Ackland ML, McArdle HJ. Significance of extracellular zinc-binding ligands in the uptake of zinc by human fibroblasts. J Cell Physiol 1990 Dec;145(3):409-13.

Aggett PJ. Aspects of neonatal metabolism of trace metals. Acta Paediatr Suppl 1994 Sep;402 :75-85.

Aggett PJ. The assessment of zinc status: a personal view. Proc Nutr Soc 1991 Mar;50(1):9-17.

Aggett PJ. Malnutrition and trace element metabolism. Nestle Nutr Worksh Ser 1990;19:155-76.

Aggett PJ. Zinc. Ann Nestle 1994;52(3):94-106.

Aggett PJ, Comerford JG. Zinc and human health. Nutr Rev 1995 Sep;53(9 Pt 2):S16-22.

Aggett PJ, Favier A. Zinc. Int J Vitam Nutr Res 1993;63(4):301-7.

Agte VV, Chiplonkar SA, Gokhale MK. Interaction of riboflavin with zinc bioavailability. Ann N Y Acad Sci 1992 Sep 30 ;669:314-6.

Agte VV, Gokhale MK, Paknikar KM, Chiplonkar SA. Assessment of pearl millet vs rice based diets for bioavailability of four trace metals. Plant Foods Hum Nutr 1995;48(2):149-58.

Agte VV, Paknikar KM, Chiplonkar SA. Effect of nicotinic acid on zinc and iron metabolism. Biometals 1997 Oct;10(4):271-6.

Ahmed F, Barua S, Mohiduzzaman M, Shaheen N, Bhuyan MA, Margetts BM, Jackson AA. Interactions between growth and nutrient status in school-age children of urban Bangladesh. Am J Clin Nutr 1993 Sep;58(3):334-8.

Ahmed F, Mohiduzzaman M, Barua S, Shaheen N, Margetts BM, Jackson AA. Effect of family size and income on the biochemical indices of urban school children of Bangladesh. Eur J Clin Nutr 1992;46(7):465-73.

Aldrian PS, Keen CL, Lonnerdal B, Dewey KG. Effects of coffee consumption on iron, zinc and copper status in nonpregnant and pregnant Sprague-Dawley rats. Int J Food Sci Nutr 1997 May ;48(3):177-89.

Alfieri MA, Leung FY, Grace DM. Selenium and zinc levels in surgical patients receiving total parenteral nutrition. Biol Trace Elem Res 1998 Jan ;61(1):33-9.

Allen LH. Child nutrition and growth: is dietary quality important for the growth and development of Third World Children? Food Nutr News 1991;63(3):15-8.

Allen LH, Rosado JL, Casterline JE, Martinez H, Lopez P, Munoz E, Black AK. Vitamin B-12 deficiency and malabsorption are highly prevalent in rural Mexican communities. Am J Clin Nutr 1995 Nov;62(5):1013-9.

Anderson AS, Campbell D, Shepherd R. Nutrition knowledge, attitude to healthier eating and dietary intake in pregnant compared to non-pregnant women. J Hum Nutr Diet 1993;6(4):335-53.

Anderson RA, Bryden NA, Polansky MM. Dietary intake of calcium, chromium, copper, iron, magnesium, manganese, and zinc: duplicate plate values corrected using derived nutrient intake. J Am Diet Assoc 1993 Apr; 93(4):462-4.

Angiolillo A, Panara F. Human liver high molecular weight zinc-dependent acid p-nitrophenylphosphatase. Purification and properties. Biol Pharm Bull 1997 Dec;20(12):1235-9.

Antal M, Regoly-Merei A, Varsanyi H, Biro L, Nagy K, Szepvolgyi J, Barna E, Gergely A, Kontraszti M, Pfaff G, Biro G. [Assessment of nutritional status of pregnant women and newborns on the basis of nutrition related biomarkers] . Ernahrungsforschung 1997;42(4):235-52. (Ger).

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Apgar J, Everett GA. The guinea pig as a model for effects of maternal nutrition on pregnancy outcome. Nutr Res 1991;11(8):929-39.

Apgar J, Everett GA, Fitzgerald JA. Dietary zinc deprivation affects parturition and outcome of pregnancy in the ewe. Nutr Res 1993;13(3):319-30.

Aquilio E, Spagnoli R, Seri S, Bottone G, Spennati G. Trace element content in human milk during lactation of preterm newborns. Biol Trace Elem Res 1996 Jan;51 (1):63-9.

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Arnaud J, Chappuis P, Jaudon MC, Bellanger J. [Nutritional biological markers of deficiencies of zinc, copper and selenium]. Ann Biol Clin (Paris) 1993;51(6):589-604. (Fre).

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Artacho R, Ruiz-Lopez MD, Gamez C, Puerta A, Lopez MC. Serum concentration and dietary intake of Zn in healthy institutionalized elderly subjects. Sci Total Environ 1997 Oct 20 ;205(2-3):159-65.

Baghurst KI, Baghurst PA, Record SJ. Demographic and nutritional profiles of people consuming varying levels of added sugars. Nutr Res 1992;12(12):1455-65.

Baghurst KI, Dreosti IE, Syrette JA, Record SJ, Baghurst PA, Buckley RA. Zinc and magnesium status of Australian adults. Nutr Res 1991 Jan;11 (1):23-32.

Bailey AL, Maisey S, Southon S, Wright AJ, Finglas PM, Fulcher RA. Relationships between micronutrient intake and biochemical indicators of nutrient adequacy in a "free-living' elderly UK population. Br J Nutr 1997 Feb ;77(2):225-42.

Bales CW, DiSilvestro RA, Currie KL, Plaisted CS, Joung H, Galanos AN, Lin PH. Marginal zinc deficiency in older adults: responsiveness of zinc status indicators. J Am Coll Nutr 1994 Oct ;13(5):455-62.

Ballew C, Sugerman SB. High-risk nutrient intakes among low-income Mexican women in Chicago, Illinois. J Am Diet Assoc 1995;95(12):1409-13.

Bankson DD, Kestin M, Rifai N. Role of free radicals in cancer and atherosclerosis. Clin Lab Med 1993;13:2463-80.

Barclay DV, Heredia L, Gil-Ramos J, Montalvo MM, Lozano R, Mena M, Dirren H. Nutritional status of institutionalised elderly in Ecuador. Arch Latinoam Nutr 1996;46(2):122-7.

Barone A, Ebesh O, Harper RG, Wapnir RA. Placental copper transport in rats: effects of elevated dietary zinc on fetal copper, iron and metallothionein. J Nutr 1998 Jun ;128(6):1037-41.

Bates CJ, Mansoor MA, van der Pols J, Prentice A, Cole TJ, Finch S. Plasma total homocysteine in a representative sample of 972 British men and women aged 65 and over. Eur J Clin Nutr 1997;51(10):691-7.

Bebe FN, Panemangalore M. Indices of zinc and copper status and blood lead in adults living in a high-lead environment. Environ Nutr Interact 1997 May-Aug; 1 (3-4):171-189.

Bedwal RS, Bahuguna A. Zinc, copper and selenium in reproduction. Experientia 1994 Jul 15 ;50(7):626-40.

Berry EM. Undernutrition in the elderly: a physiological or pathological process? Nestle Nutr Worksh Ser 1992;29:65-73.

Beshgetoor D, Lonnerdal B. Effect of marginal maternal zinc deficiency in rats on mammary gland zinc metabolism. J Nutr Biochem 1997;8(10):573-8.

Bettger WJ, O'Dell BL. Physiological roles of zinc in the plasma membrane of mammalian cells. J Nutr Biochem 1993 Apr;4 (4):194-207.

Beutler KT, Pankewycz O, Brautigan DL. Equivalent uptake of organic and inorganic zinc by monkey kidney fibroblasts, human intestinal epithelial cells, or perfused mouse intestine. Biol Trace Elem Res 1998 Jan ;61(1):19-31.

Bhaskaram P, Hemalatha P. Zinc status of Indian children. Indian J Med Res 1995 Nov ;102 :210-15.

Bhaskaram P, Hemalatha P, Islam A, Dewey KG, Heinig MJ, Nommsen LA, Lonnerdal B. Zinc status in breastfed infants . Lancet 1992;340(8832):1416-7.

Bhutta ZA. The role of zinc in health and disease: relevance to child health in developing countries. JPMA J Pak Med Assoc 1997 Feb ;47(2):68-73.

Bin QH, Garfinkel D. The cadmium toxicity hypothesis of aging: a possible explanation for the zinc deficiency hypothesis of aging. Med Hypotheses 1994 Jun ;42(6):380-4.

Biro G, Antal M, Zajkas G. Nutrition survey of the Hungarian population in a randomized trial between 1992-1994. Eur J Clin Nutr 1996;50(4):201-8.

Black RE, guest scientific editor. Zinc for child health: proceedings of a symposium held in Baltimore, Maryland, November 17-19, 1996. Am J Clin Nutr 1998 Aug;68(2 Suppl):409S-516S.

Block G, Abrams B. Vitamin and mineral status of women of childbearing potential. Ann N Y Acad Sci 1993;678:244-54.

Boukaiba N, Flament C, Acher S, Chappuis P, Dardenne M, Lemonnier D. [Effects of zinc supplementation on nutritional and immune status in an elderly population] . Cahiers Nutr Diet 1995;30(6):371-7. (Fre).

Boukaiba N, Flament C, Acher S, Chappuis P, Piau A, Fusselier M, Dardenne M, Lemonnier D. A physiological amount of zinc supplementation: effects on nutritional, lipid, and thymic status in an elderly population. Am J Clin Nutr 1993 Apr ;57(4):566-72.

Brandao-Neto J, Stefan V, Mendonca BB, Bloise W, Castro AV. The essential role of zinc in growth. Nutr Res 1995;15(3):335-8.

Brando-Neto J, Shuhama T, Pimenta WP, et al. Renal excretion of zinc in normal individuals during zinc tolerance test and glucose tolerance test. Trace Elem Electrolytes 1995;12:62-7.

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Bremner I, Beattie JH. Copper and zinc metabolism in health and disease: speciation and interactions. Proc Nutr Soc 1995 Jul ;54(2):489-99.

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Brown KH, Lanata CF, Yuen ML, Peerson JM, Butron B, Lonnerdal B. Potential magnitude of the misclassification of a population's trace element status due to infection: example from a survey of young Peruvian children. Am J Clin Nutr 1993 Oct ;58(4):549-54.

Browning JD, MacDonald RS, Thornton WH, O'Dell BL. Reduced food intake in zinc deficient rats is normalized by megestrol acetate but not by insulin-like growth factor-I. J Nutr 1998 Jan ;128(1):136-42.

Brun JF, Dieu-Cambrezy C, Charpiat A, Fons C, Fedou C, Micallef JP, Fussellier M, Bardet L, Orsetti A. Serum zinc in highly trained adolescent gymnasts. Biol Trace Elem Res 1995 Jan-Mar ;47(1-3):273-8.

Buchman AL, Keen C, Commisso J, Killip D, Ou CN, Rognerud CL, Dennis K, Dunn JK. The effect of a marathon run on plasma and urine mineral and metal concentrations. J Am Coll Nutr 1998 Apr ;17(2):124-7.

Bui LM, Dressendorfer RH, Keen CL, Summary JJ, Dubick MA. Zinc status and interleukin-1 beta-induced alterations in mineral metabolism in rats. Proc Soc Exp Biol Med 1994 Sep ;206(4):438-44.

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Cao J, Chavez ER. The effects of low dietary copper intake during pregnancy on physiological fluids and reproductive performance of first-litter gilts. J Trace Elem Med Biol 1995;9(1):18-27.

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Carruth BR, Nevling W, Skinner JD. Developmental and food profiles of infants born to adolescent and adult mothers. J Adolesc Health 1997;20(6):434-41.

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Chausmer AB. Zinc, insulin and diabetes. J Am Coll Nutr 1998 Apr ;17(2):109-15.

Chawla PK, Puri R. Impact of nutritional supplements on hematological profile of pregnant women. Indian Pediatr 1995;32(8):876-80.

Chen XC, Wang WG, Yan HC, Yin TA, Xu QM. Studies on iron deficiency anemia, rickets and zinc deficiency and their prevention among Chinese preschool children. Prog Food Nutr Sci 1992 Oct-Dec;16(4):263-77.

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Chunga Vega F, Gomez de Tejada MJ, Gonzalez Hachero J, Perez Cano R, Coronel Rodriguez C. Low bone mineral density in small for gestational age infants: correlation with cord blood zinc concentrations. Arch Dis Child Fetal Neonatal Ed 1996 Sep;75(2):F126-9.

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Coudray C, Richard M J, Laporte F, Faure P, Roussel A M, Favier A. Superoxide dismutase activity and zinc status: a study in animals and man. J Nutral Med 1992;3(1):13-26.

Cousins RJ. Zinc. In: Ziegler EE, Filer LJ, editors . Present knowledge in nutrition. 7th . Washington: ILSI Press; 1996. p. 293-306.

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Crawley HF, While D. The diet and body weight of British teenage smokers at 16-17 years. Eur J Clin Nutr 1995;49(12):904-14.

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Cunningham BC, Mulkerrin MG, Wells JA. Dimerization of human growth hormone by zinc. Science 1991 Aug 2 ;253(5019):545-8.

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Darmon N, Pelissier MA, Candalh C, Chappuis P, Blaton MA, Albrecht R, Desjeux JF, Heyman M. Zinc and intestinal anaphylaxis to cow's milk proteins in malnourished guinea pigs. Pediatr Res 1997 Aug ;42(2):208-13.

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Deuster PA, Gallagher KL, Singh A, Reynolds RD. Consumption of a dehydrated ration for 31 days at moderate altitudes: status of zinc, copper, and vitamin B-6. J Am Diet Assoc 1992 Nov ;92(11):1372-5.

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Dewey KG, Heinig MJ, Nommsen LA, Lonnerdal B. Zinc status in breastfed infants [letter]. Lancet 1992 Dec 5 ;340(8832):1417. Comment on: Lancet 1992 Sep 19;340(8821):683-5.

Di Toro A, Marotta A, Todisco N, Ponticiello E, Collini R, Di Lascio R, Perrone L. Unchanged iron and copper and increased zinc in the blood of obese children after two hypocaloric diets. Biol Trace Elem Res 1997 May ;57(2):97-104.

Dimai HP, Hall SL, Stilt-Coffing B, Farley JR. Skeletal response to dietary zinc in adult female mice. Calcif Tissue Int 1998 Apr ;62(4):309-15.

Dirren H, Barclay D, Ramos JG, Lozano R, Montalvo MM, Davila N, Mora JO. Zinc supplementation and child growth in Ecuador. Adv Exp Med Biol 1994;352:215-22.

Dolev E, Burstein R, Lubin F, Wishnizer R, Chetrit A, Shefi M, Deuster PA. Interpretation of zinc status indicators in a strenuously exercising population. J Am Diet Assoc 1995;95(4):482-4.

Donma O, Gunbey S, Tas MA, Donma MM. Zinc, copper, and magnesium concentrations in hair of children from southeastern Turkey. Biol Trace Elem Res 1990 Jan ;24(1):39-47.

Donovan UM, Gibson RS. Dietary intakes of adolescent females consuming vegetarian, semi- vegetarian, and omnivorous diets. J Adolesc Health 1996;18(4):292-300.

Donovan UM, Gibson RS. Iron and zinc status of young women aged 14 to 19 years consuming vegetarian and omnivorous diets. J Am Coll Nutr 1995 Oct ;14(5):463-72.

Doran L, Evers S. Energy and nutrient inadequacies in the diets of low-income women who breast-feed. J Am Diet Assoc 1997;97(11):1283-7.

Dorea JG. Concentration of zinc, copper and metallocalorie ratio in bottle-milks prepared by poor urban families. Ann Trop Paediatr 1992;12(1):7-11.

Dorea JG. Is zinc a first limiting nutrient in human milk? Nutr Res 1993;13(6):659-66.

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ZINC AND THE GASTROINTESTINAL TRACT

Zinc and copper wastage during acute diarrhea. Nutr Rev 1990 Jan ;48(1):19-22.

Abdel-Mageed AB, Oehme FW. The effect of various dietary zinc concentrations on the biological interactions of zinc, copper, and iron in rats. Biol Trace Elem Res 1991 Jun;29(3):239-56.

Abrams SA, Wen J, Stuff JE. Absorption of calcium, zinc, and iron from breast milk by five- to seven-month-old infants . Pediatr Res 1997 Mar ;41(3):384-90. Published erratum appears in Pediatr Res 1997 Jun;41(6):814.

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Agte VV, Chiplonkar SA, Gokhale MK. Interaction of riboflavin with zinc bioavailability. Ann N Y Acad Sci 1992 Sep 30 ;669:314-6.

Akar N, Bahceci M, Uckan D, Dincer N, Yavuz H, Cavdar AO. Maternal plasma zinc levels after oral zinc tolerance test in pregnancies associated with neural tube defects in Turkey. J Trace Elem Exp Med 1991;4(4):225-7.

Aldrian PS, Keen CL, Lonnerdal B, Dewey KG. Effects of coffee consumption on iron, zinc and copper status in nonpregnant and pregnant Sprague-Dawley rats. Int J Food Sci Nutr 1997 May ;48(3):177-89.

Amini SA, Walsh K, Dunstan R, Dunkley PR, Murdoch RN. Maternal hepatic, endometrial, and embryonic levels of Zn, Mg, Cu, and Fe following alcohol consumption during pregnancy in QS mice. Res Commun Alcohol Subst Abuse 1995;16(4):207-19.

Andersen O, Nielsen JB, Sorensen JA, Scherrebeck L. Experimental localization of intestinal uptake sites for metals (Cd, Hg, Zn, Se) in vivo in mice. Environ Health Perspect 1994 Sep ;102(3 Suppl ):199-206.

Argiratos V, Samman S. The effect of calcium carbonate and calcium citrate on the absorption of zinc in healthy female subjects. Eur J Clin Nutr 1994 Mar ;48(3):198-204.

Aysenur Pac F, Yigitoglu R, Arcasoy A. Effect of long-term oral zinc supplementation on oral plasma zinc tolerance test in malnutrition. J Trace Elem Exp Med 1992;5(4):215-20.

Bates CJ, Evans PH, Dardenne M, Prentice A, Lunn PG, Northrop-Clewes CA, Hoare S, Cole TJ, Horan SJ, Longman SC, Stirling D, Aggett PJ. A trial of zinc supplementation in young rural Gambian children. Br J Nutr 1993 Jan;69(1):243-55.

Behrens RH, Tomkins AM, Roy SK. Zinc supplementation during diarrhoea, a fortification against malnutrition? Lancet 1990 Aug. 18;336:442-3.

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Blanchard RK, Cousins RJ. Upregulation of rat intestinal uroguanylin mRNA by dietary zinc restriction. Am J Physiol 1997 May ;272(5 Pt 1):G972-8.

Brommage R, Binacua C, Carrie AL. Ovulation-associated increase in intestinal calcium absorption during the rat estrous cycle is blunted by ovariectomy. Biol Reprod 1993 Sep ;49(3):544-8.

Browning JD, MacDonald RS, Thornton WH, O'Dell BL. Reduced food intake in zinc deficient rats is normalized by megestrol acetate but not by insulin-like growth factor-I. J Nutr 1998 Jan ;128(1):136-42.

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Cheng J, Kornegay ET, Schell T. Influence of dietary lysine on the utilization of zinc from zinc sulfate and a zinc-lysine complex by young pigs. J Anim Sci 1998 Apr;76(4):1064-74.

Chierici R, Vigi V. Dietary trace elements in early infancy. Beitr Infusionsther 1991;27:66-85.

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Cho CH. Zinc: absorption and role in gastrointestinal metabolism and disorders. Dig Dis 1991;9(1):49-60.

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Coudray C, Bellanger J, Castiglia-Delavaud C, Remesy C, Vermorel M, Rayssignuier Y. Effect of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. Eur J Clin Nutr 1997 Jun ;51(6):375-80.

Cousins RJ, Lee-Ambrose LM. Nuclear zinc uptake and interactions and metallothionein gene expression are influenced by dietary zinc in rats. J Nutr 1992 Jan ;122(1):56-64.

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Dalton T, Fu K, Palmiter RD, Andrews GK. Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency. J Nutr 1996 Apr ;126(4):825-33.

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Davidsson L, Almgren A, Sandstrom B, Juillerat M, Hurrell RF. Zinc absorption in adult humans: the effect of protein sources added to liquid test meals. Br J Nutr 1996 Apr ;75(4):607-13.

Davidsson L, Mackenzie J, Kastenmayer P, Aggett PJ, Hurrell RF. Zinc and calcium apparent absorption from an infant cereal: a stable isotope study in healthy infants. Br J Nutr 1996 Feb ;75(2):291-300.

Davidsson L, Mackenzie J, Kastenmayer P, Rose A, Golden BE, Aggett PJ, Hurrell RF. Dietary fiber in weaning cereals: a study of the effect on stool characteristics and absorption of energy, nitrogen, and minerals in healthy infants. J Pediatr Gastroenterol Nutr 1996 Feb ;22(2):167-79.

Davis SR, McMahon RJ, Cousins RJ. Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. J Nutr 1998 May ;128(5):825-31.

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Dijkstra M, Havinga R, Vonk RJ, Kuipers F. Bile secretion of cadmium, silver, zinc and copper in the rat. Involvement of various transport systems. Life Sci 1996;59(15):1237-46.

Dintzis FR, Laszlo JA, Nelsen TC, Baker FL, Calvert CC. Free and total ion concentrations in pig digesta. J Anim Sci 1995 Apr ;73(4):1138-46.

DiSilvestro RA, Medeiros DM. Low and marginal copper intake by postweanling rats effects on copper status and resistance to carbon tetrachloride hepatotoxicity. Metab Clin Exp 1992;41(10):1122-4.

Dreosti IE. Recommended dietary intakes of iron, zinc, and other inorganic nutrients and their chemical form and bioavailability . Nutrition 1993 Nov-Dec ;9(6):542-5. Comment in Nutrition 1993 Nov-Dec;9(6):563-4.

Du Z, Hemken RW, Jackson JA, Trammell DS. Utilization of copper in copper proteinate, copper lysine, and cupric sulfate using the rat as an experimental model. J Anim Sci 1996 Jul ;74(7):1657-63.

Dursun N, Aydogan S. The influence of dietary iron on zinc in rat. Biol Trace Elem Res 1995 May ;48(2):161-71.

Easley D, Krebs N, Jefferson M, Miller L, Erskine J, Accurso F, Hambidge KM. Effect of pancreatic enzymes on zinc absorption in cystic fibrosis. J Pediatr Gastroenterol Nutr 1998 Feb;26(2):136-9.

Ecelbarger CA, Greger JL. Dietary citrate and kidney function affect aluminum, zinc and iron utilization in rats. J Nutr 1991 Nov ;121(11):1755-62.

Eder K, Kirchgessner M. Zinc deficiency and the desaturation of linoleic acid in rats force-fed fat-free diets. Biol Trace Elem Res 1996 Aug ;54(2):173-83.

Eide D. Molecular biology of iron and zinc uptake in eukaryotes. Curr Opin Cell Biol 1997 Aug ;9(4):573-7.

Elhardallou SB, Walker AF. Binding of Ca by three starchy legumes in the presence of Ca alone or with Fe, Zn, Mg and Cu. Food Chem 1995;52(4):379-84.

Ellwood KC, Roebuck BD, Hathcock JN. Marginal zinc status does not exacerbate pancreatic carcinogenesis associated with dietary soybean trypsin inhibitor concentrate in rats. J Nutr 1994 Jun ;124(6):894-900.

Elsenhans B, Kolb K, Schumann K, Forth W. The longitudinal distribution of cadmium, zinc, copper, iron, and metallothionein in the small-intestinal mucosa of rats after administration of cadmium chloride. Biol Trace Elem Res 1994;41(1-2):31-46.

Engelmann MD, Sandstrom B, Michaelsen KF. Meat intake and iron status in late infancy: an intervention study. J Pediatr Gastroenterol Nutr 1998 Jan ;26(1):26-33.

Escobar O, Sandoval M, Vargas A, Hempe JM. Role of metallothionein and cysteine-rich intestinal protein in the regulation of zinc absorption by diabetic rats. Pediatr Res 1995 Mar ;37(3):321-7.

Fairweather-Tait SJ. From absorption and excretion of minerals--to the importance of bioavailability and adaptation. Br J Nutr 1997 Nov;78 (Suppl):S95-100.

Fairweather-Tait SJ. Iron-zinc and calcium-Fe interactions in relation to Zn and Fe absorption. Proc Nutr Soc 1995 Jul ;54(2):465-73.

Fairweather-Tait SJ, Fox TE, Wharf SG, Eagles J, Crews HM, Massey R. Apparent zinc absorption by rats from foods labelled intrinsically and extrinsically with 67Zn. Br J Nutr 1991 Jul ;66(1):65-71.

Fairweather-Tait SJ, Fox TE, Wharf SG, Eagles J, Kennedy H. Zinc absorption in adult men from a chicken sandwich made with white or wholemeal bread, measured by a double-label stable-isotope technique. Br J Nutr 1992 May;67(3):411-9.

Fairweather-Tait SJ, Wharf SG, Fox TE. Zinc absorption in infants fed iron-fortified weaning food. Am J Clin Nutr 1995 Oct ;62(4):785-9.

Fairweather-Tait SJ, Wright AJ. The effects of sugar-beet fibre and wheat bran on iron and zinc absorption in rats . Br J Nutr 1990 Sep ;64(2):547-52. Comment in Br J Nutr 1991 May;65(3):505-6.

Fenwick PK, Aggett PJ, Macdonald D, Huber C, Wakelin D. Zinc deficiency and zinc repletion: effect on the response of rats to infection with Trichinella spiralis. Am J Clin Nutr 1990 Jul ;52(1):166-72.

Fenwick PK, Aggett PJ, Macdonald DC, Huber C, Wakelin D. Zinc deprivation and zinc repletion: effect on the response of rats to infection with Strongyloides ratti. Am J Clin Nutr 1990 Jul ;52(1):173-7.

Fernandes PR, Samuelson DA, Clark WR, Cousins RJ. Immunohistochemical localization of cysteine-rich intestinal protein in rat small intestine. Am J Physiol 1997 Apr;272(4 Pt 1):G751-9.

Fernandez-Lopez JA, Esteve M, Rafecas I, Remesar X, Alemany M. Management of dietary essential metals (iron, copper, zinc, chromium and manganese) by Wistar and Zucker obese rats fed a self-selected high-energy diet. Biometals 1994 Apr ;7(2):117-29.

Ficarra G, Cicchi P, Amorosi A, Piluso S. Oral Crohn's disease and pyostomatitis vegetans. An unusual association. Oral Surg Oral Med Oral Pathol 1993 Feb ;75(2):220-4.

Finley JW, Johnson PE, Reeves PG, Vanderpool RA, Briske-Anderson M. Effect of bile/pancreatic secretions on absorption of radioactive or stable zinc. In vivo and in vitro studies. Biol Trace Elem Res 1994 Aug ;42(2):81-96.

Fleet JC, Turnbull AJ, Bourcier M, Wood RJ. Vitamin D-sensitive and quinacrine-sensitive zinc transport in human intestinal cell line Caco-2. Am J Physiol 1993 Jun ;264(6 Pt 1):G1037-45.

Flora SJ, Kumar D, Das Gupta S. Interaction of zinc, methionine or their combination with lead at gastrointestinal or post-absorptive level in rats. Pharmacol Toxicol 1991 Jan ;68(1):3-7.

Folwaczny C. Zinc and diarrhea in infants. J Trace Elem Med Biol 1997 Jun ;11(2):116-22.

Fong LY, Li JX, Farber JL, Magee PN. Cell proliferation and esophageal carcinogenesis in the zinc-deficient rat. Carcinogenesis 1996 Sep ;17(9):1841-8.

Foulkes EC. Further findings on the mechanism of cadmium uptake by intestinal mucosal cells (step 1 of Cd absorption). Toxicology 1991;70(3):261-70.

Fox TE, Fairweather-Tait SJ, Eagles J, Wharf SG. Intrinsic labelling of different foods with stable isotope of zinc (67Zn) for use in bioavailability studies. Br J Nutr 1991 Jul ;66(1):57-63.

Friis H, Ndhlovu P, Mduluza T, Kaondera K, Sandstrom B, Michaelsen KF, Vennervald BJ, Christensen NO. The impact of zinc supplementation on growth and body composition: a randomized, controlled trial among rural Zimbabwean schoolchildren. Eur J Clin Nutr 1997 Jan ;51(1):38-45.

Fung EB, Ritchie LD, Woodhouse LR, Roehl R, King JC. Zinc absorption in women during pregnancy and lactation: a longitudinal study. Am J Clin Nutr 1997 Jul;66(1):80-8.

Furuta S, Toyama S, Miwa M, Sano H. Disposition of polaprezinc (zinc L-carnosine complex) in rat gastrointestinal tract and effect of cimetidine on its adhesion to gastric tissues. J Pharm Pharmacol 1995;47(8):632-36.

Furuta S, Toyama S, Sano H. Absorption mechanism of polaprezinc (zinc L-carnosine complex) by an everted sac method. Xenobiotica 1994 Nov ;24(11):1085-94.

Gachot B, Poujeol P. Effects of cadmium and copper on zinc transport kinetics by isolated renal proximal cells. Biol Trace Elem Res 1992 Nov ;35(2):93-103.

Gachot B, Tauc M, Morat L, Poujeol P. Zinc uptake by proximal cells isolated from rabbit kidney: effects of cysteine and histidine. Pflugers Arch 1991 Dec ;419(6):583-7.

Gachot B, Tauc M, Wanstok F, Morat L, Poujeol P. Zinc transport and metallothionein induction in primary cultures of rabbit kidney proximal cells. Biochim Biophys Acta 1994 May 11 ;1191(2):291-8.

Galibois I, Desrosiers T, Guevin N, Lavigne C, Jacques H. Effects of dietary fibre mixtures on glucose and lipid metabolism and on mineral absorption in the rat. Ann Nutr Metab 1994;38(4):203-11.

Garcia-Arias MT, Castrillon AM, Navarro MP. Bioavailability of zinc in rats fed on tuna as a protein source in the diet. J Trace Elem Electrolytes Health Dis 1993;6(5):29-36.

Gibson RS, Smit Vanderkooy PD, Thompson L. Dietary phytate x calcium/zinc millimolar ratios and zinc nutriture in some Ontario preschool children. Biol Trace Elem Res 1991 Jul ;30(1):87-94.

Gifford SR, Clydesdale FM. Interactions among calcium, zinc and phytate with three protein sources. J Food Sci 1990;6:1720-4.

Gitlin JD, Schroeder JJ, Lee-Ambrose LM, Cousins RJ. Mechanisms of caeruloplasmin biosynthesis in normal and copper-deficient rats. Biochem J 1992 Mar 15 ;282(Pt 3):835-9.

Golub MS, Gershwin ME, Lonnerdal B, Keen CL, Hurley LS, Hendrickx AG. Problems associated with long-term feeding of purified diets in rhesus monkeys. Primates 1990;31(4):579-88.

Golub MS, Tarantal AF, Gershwin ME, Keen CL, Hendrickx AG, Lonnerdal B. Ultrasound evaluation of fetuses of zinc-deprived monkeys (Macaca mulatta). Am J Clin Nutr 1992 Mar ;55(3):734-40.

Gomez-Ayala AE, Campos MS, Lopez-Aliaga I, Pallares I, Hartiti S, Barrionuevo M, Alferez MJ, Rodriguez-Matas MC, Lisbona F. Effect of source of iron on duodenal absorption of iron, calcium, phosphorous, magnesium, copper and zinc in rats with ferropoenic anaemia. Int J Vitam Nutr Res 1997;67(2):106-14.

Gomez-Ayala AE, Lisbona F, Lopez-Aliaga I, Pallares I, Barrionuevo M, Hartiti S, Rodriguez-Matas MC, Campos MS. The absorption of iron, calcium, phosphorus, magnesium, copper and zinc in the jejunum-ileum of control and iron-deficient rats. Lab Anim 1998 Jan ;32(1):72-9.

Goode HF, Robertson DA, Kelleher J, Walker BE. Effect of fasting, self-selected and isocaloric glucose and fat meals and intravenous feeding on plasma zinc concentrations. Ann Clin Biochem 1991 Sep ;28(Pt 5):442-5.

Gralak MA, Leontowicz M, Morawiec M, Bartnikowska E, Kulasek GW. Comparison of the influence of dietary fibre sources with different proportions of soluble and insoluble fibre on Ca, Mg, Fe, Zn, Mn and Cu apparent absorption in rats. Arch Anim Nutr 1996;49(4):293-9.

Grotz N, Fox T, Connolly E, Park W, Guerinot ML, Eide D. Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency. Proc Natl Acad Sci U S A 1998 Jun 9 ;95(12):7220-4.

Hallquist NA, Khoo C, Cousins RJ. Lipopolysaccharide regulates cysteine-rich intestinal protein, a zinc-finger protein, in immune cells and plasma. J Leukoc Biol 1996 Feb ;59(2):172-7.

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ZINC AND THE IMMUNE SYSTEM, ANTIOXIDANT, AND DEFENSE FUNCTIONS

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Yamasaki Y, Suzuki T, Yamaya H, Matsuura N, Onodera H, Kogure K. Possible involvement of interleukin-1 in ischemic brain edema formation. Neurosci Lett 1992;142(1):45-7.

Yang BS, Ishii H, Satoh A, Kato N. Supplemental dietary cystine elevates kidney metallothionein in rats by a mechanism involving altered zinc metabolism. J Nutr 1995 May;125(5):1167-74.

Yang D, Rogers MV, Brett SJ, Liew FY. Immunological analysis of the zinc-binding peptides of surface metalloproteinase (gp63) of Leishmania major. Immunology 1993 Apr;78(4):582-5.

Yang YY, Woo ES, Reese CE, Bahnson RR, Saijo N, Lazo JS. Human metallothionein isoform gene expression in cisplatin-sensitive and resistant cells. Mol Pharmacol 1994 Mar ;45(3):453-60.

Yasui DH, Genetta T, Kadesch T, Williams TM, Swain SL, Tsui LV, Huber BT. Transcriptional repression of the IL-2 gene in Th cells by ZEB. J Immunol 1998 May 1 ;160(9):4433-40.

Yen HC, Oberley TD, Vichitbandha S, Ho YS, St Clair DK. The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest 1996;98(5):1253-60.

Yin XM, Oltvai ZN, Veis-Novack DJ, Linette GP, Korsmeyer SJ. Bcl-2 gene family and the regulation of programmed cell death. Cold Spring Harb Symp Quant Biol 1994;59:387-93.

Yoshikawa T, Minamiyama Y, Ichikawa H, Takahashi S, Naito Y, Kondo M. Role of lipid peroxidation and antioxidants in gastric mucosal injury induced by the hypoxanthine-xanthine oxidase system in rats. Free Radic Biol Med 1997;23(2):243-50.

Yoshikawa T, Naito Y, Tanigawa T, Yoneta T, Kondo M. The antioxidant properties of a novel zinc-carnosine chelate compound, N-(3-aminopropionyl)-L-histidinato zinc. Biochim Biophys Acta 1991 Nov 14 ;1115(1):15-22.

Yu CW, Chen JH, Lin LY. Metal-induced metallothionein gene expression can be inactivated by protein kinase C inhibitor. FEBS Lett 1997 Dec 22 ;420(1):69-73.

Yuan HT, Bingle CD, Kelly FJ. Differential patterns of antioxidant enzyme mRNA expression in guinea pig lung and liver during development. Biochim Biophys Acta 1996;1305(3):163-71.

Yucel D, Aydogdu S, Cehreli S, Saydam G, Canatan H, Senes M, Topkaya BC, Nebioglu S. Increased oxidative stress in dilated cardiomyopathic heart failure. Clin Chem 1998;44(1):148-54.

Yui S, Mikami M, Tsurumaki K, Yamazaki M. Growth-inhibitory and apoptosis-inducing activities of calprotectin derived from inflammatory exudate cells on normal fibroblasts: regulation by metal ions. J Leukoc Biol 1997 Jan;61(1):50-7.

Yui S, Mikami M, Yamazaki M. Induction of apoptotic cell death in mouse lymphoma and human leukemia cell lines by a calcium-binding protein complex, calprotectin, derived from inflammatory peritoneal exudate cells. J Leukoc Biol 1995 Dec ;58(6):650-8.

Zalewski PD. Zinc and immunity: implications for growth, survival and function of lymphoid cells. J Nutr Immunol 1996;4(3):39-101.

Zalewski PD, Forbes IJ, Betts WH. Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II). Biochem J 1993 Dec 1;296(Pt 2):403-8.

Zalewski PD, Forbes IJ, Giannakis C. Physiological role for zinc in prevention of apoptosis (gene-directed death). Biochem Int 1991 Aug;24(6):1093-101.

Zalewski PD, Forbes IJ, Giannakis C, Betts WH. Regulation of protein kinase C by Zn(2+)-dependent interaction with actin. Biochem Int 1991 Aug;24(6):1103-10.

Zalewski PD, Forbes IJ, Seamark RF, Borlinghaus R, Betts WH, Lincoln SF, Ward AD. Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin. Chem Biol 1994 Nov;1(3):153-61.

Zhao M, Matter K, Laissue JA, Zimmermann A. Copper/zinc and manganese superoxide dismutase in alcoholic liver disease: immunohistochemical quantitation. Histol Histopathol 1996;11(4):899-907.

Zhong W, Oberley L, Oberley TD, Yan T, Domann FE, St Clair DK. Inhibition of cell growth and sensitization of oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells. Cell Growth Differ 1996;7(9):1175-86.

Zhong W, Zhang Q, Yan Y, Yue S, Zhang B, Tang W. Reaction of a platinum(IV) complex with native Cd,Zn-metallothionein in vitro. J Inorg Biochem 1997 May 15;66(3):179-85.

Zidenberg-Cherr S, Olin KL, Villanueva J, Tang A, Phinney SD, Halsted CH, Keen CL. Ethanol-induced changes in hepatic free radical defense mechanisms and fatty-acid composition in the miniature pig. Hepatology (Baltimore) 1991;13(6):1185-92.

Zini A, Schlegel PN. Cu-Zn superoxide dismutase, catalase and glutathione peroxidase mRNA expression in the rat testis after surgical cryptorchidism and efferent duct ligation. J Urol 1997 Aug;158(2):659-63.

Zini A, Schlegel PN. Identification and characterization of antioxidant enzyme mRNAs in the rat epididymis. Int J Androl 1997 Apr;20(2):86-91.

Zwacka RM, Dudus L, Epperly MW, Greenberger JS, Engelhardt JF. Redox gene therapy protects human IB-3 lung epithelial cells against ionizing radiation-induced apoptosis. Hum Gene Ther 1998;9(9):1381-6.

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ZINC AND CELLULAR MECHANISMS

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. The Finnish-German APECED Consortium. Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy. Nat Genet 1997 Dec;17(4):399-403.

Importance of zinc for hormone binding and signal transduction: limiting mechanisms in zinc deficiency? Nutr Rev 1991 Dec;49(12):369-70.

Mutations in the copper- and zinc-containing superoxide dismutase gene are associated with "Lou Gehrig's Disease". Nutr Rev 1993 Aug;51(8):243-5.

The nucleocapsid protein isolated for HIV-1 particles binds zinc and forms retroviral-type zinc fingers [editorial]. Dis Markers 1991 Jan-Feb;9(1):60.

Aasland R, Gibson TJ, Stewart AF. The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci 1995 Feb;20(2):56-9.

Abdel-Mageed AB, Agrawal KC. Activation of nuclear factor kappaB: potential role in metallothionein-mediated mitogenic response. Cancer Res 1998 Jun 1 ;58(11):2335-8.

Abdel-Mageed AB, Oehme FW. A review of the biochemical roles, toxicity and interactions of zinc, copper and iron: I. Zinc. Vet Hum Toxicol 1990 Feb ;32(1):34-9.

Abdollahi A, Godwin AK, Miller PD, Getts LA, Schultz DC, Taguchi T, Testa JR, Hamilton TC. Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells. Cancer Res 1997 May 15 ;57(10):2029-34.

Abdollahi A, Roberts D, Godwin AK, Schultz DC, Sonoda G, Testa JR, Hamilton TC. Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors. Oncogene 1997 Apr 24 ;14(16):1973-9.

Abe K, Kawagoe J, Sato S, Sahara M, Kogure K. Induction of the 'zinc finger' gene after transient focal ischemia in rat cerebral cortex. Neurosci Lett 1991 Feb 25 ;123(2):248-50.

Abrink M, Aveskogh M, Hellman L. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. DNA Cell Biol 1995 Feb ;14(2):125-36.

Abshire MK, Buzard GS, Shiraishi N, Waalkes MP. Induction of c-myc and c-jun proto-oncogene expression in rat L6 myoblasts by cadmium is inhibited by zinc preinduction of the metallothionein gene. J Toxicol Environ Health 1996 Jul ;48(4):359-77.

Ackland ML, McArdle HJ. Zinc uptake by human fibroblasts: evidence for a potassium-mediated process. J Physiol 1992;446:30.

Adler DA, Bressler SL, Chapman VM, Page DC, Disteche CM. Inactivation of the Zfx gene on the mouse X chromosome. Proc Natl Acad Sci U S A 1991 Jun1;88(11):4592-5. Published erratum appears in Proc Natl Acad Sci U S A 1991 Jul 1;88(13):5937.

Adler HT, Nallaseth FS, Walter G, Tkachuk DC. HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A. J Biol Chem 1997 Nov 7;272(45):28407-14.

Agarwal K, Baek KH, Jeon CJ, Miyamoto K, Ueno A, Yoon HS. Stimulation of transcript elongation requires both the zinc finger and RNA polymerase II binding domains of human TFIIS. Biochemistry 1991 Aug 6 ;30(31):7842-51.

Ahluwalia B, Rajguru S, Westney LS, Kaul L. Zinc inhibits protein phosphorylation in isolated sperm head membranes in Spisula solidissima. Andrologia 1991 Mar-Apr;23(2):121-6.

Ahmad W, Faiyazul Haque M, Brancolini V, Tsou HC, ul Haque S, Lam H, Aita VM, Owen J, de Blaquiere M, Frank J, Cserhalmi-Friedman PB, Leask A, McGrath JA, Peacocke M, Ahmad M, Ott J, Christiano AM. Alopecia universalis associated with a mutation in the human hairless gene. Science 1998 Jan 30;279(5351):720-4.

Aicher WK, Heer AH, Trabandt A, Bridges SL Jr, Schroeder HW Jr, Stransky G, Gay RE, Eibel H, Peter HH, Siebenlist U. Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients [published erratum appears in J Immunol 1994 Dec 1;153(11):5347]. J Immunol 1994 Jun 15 ;152(12):5940-8.

Ait-Oukhatar N, Bureau F, Boudey M, Place C, Jauzac P, Drosdowsky MA, Arhan P, Bougle D. Determination of metallothioneins by HPLC: application to zinc metabolism. Ann Biol Clin (Paris) 1996;54(2):87-90.

Akbar SA, Nicolaides KH, Brown PR. The localisation of copper-zinc superoxide dismutase in human normal term placenta by an immunofluorescence technique. J Obstet Gynaecol (Abingdon) 1998;18(1):44-6.

Alam AN, Sarker SA, Wahed MA, Khatun M, Rahaman MM. Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation. Gut 1994 Dec ;35(12):1707-11.

Albagli O, Dhordain P, Deweindt C, Lecocq G, Leprince D. The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins. Cell Growth Differ 1995 Sep ;6(9):1193-8.

Alder GM, Arnold WM, Bashford CL, Drake AF, Pasternak CA, Zimmermann U. Divalent cation-sensitive pores formed by natural and synthetic melittin and by Triton X-100. Biochim Biophys Acta 1991 Jan 9 ;1061(1):111-20.

Alexander RS, Kiefer LL, Fierke CA, Christianson DW. Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form. Biochemistry 1993 Feb 16;32(6):1510-8.

Alonso JI, Martin-Mateo MC. Induction and characterization of metallothionein in different organs of Ostrea edulis L. Biol Trace Elem Res 1996 Summer ;53(1-3):85-94.

Altamura N, Groudinsky O, Dujardin G, Slonimski PP. NAM7 nuclear gene encodes a novel member of a family of helicases with a Zn-ligand motif and is involved in mitochondrial functions in Saccharomyces cerevisiae. J Mol Biol 1992 Apr 5 ;224(3):575-87.

Amero SA, Elgin SC, Beyer AL. A unique zinc finger protein is associated preferentially with active ecdysone-responsive loci in Drosophila. Genes Dev 1991 Feb ;5(2):188-200.

Amero SA, Kretsinger RH, Moncrief ND, Yamamoto KR, Pearson WR. The origin of nuclear receptor proteins: a single precursor distinct from other transcription factors. Mol Endocrinol 1992 Jan ;6(1):3-7.

Amini SA, Walsh K, Dunstan R, Dunkley PR, Murdoch RN. Maternal hepatic, endometrial, and embryonic levels of Zn, Mg, Cu, and Fe following alcohol consumption during pregnancy in QS mice. Res Commun Alcohol Subst Abuse 1995;16(4):207-19.

Amstad P, Moret R, Cerutti P. Glutathione peroxidase compensates for the hypersensitivity of Cu,Zn- superoxide dismutase overproducers to oxidant stress. J Biol Chem 1994;269(3):1606-9.

An Z, Zhao Q, McEvoy J, Yuan WM, Markley JL, Leong SA. The second finger of Urbs1 is required for iron-mediated repression of sid1 in Ustilago maydis. Proc Natl Acad Sci U S A 1997 May 27 ;94(11):5882-7.

Ancsin JB, Kisilevsky R. Laminin interactions important for basement membrane assembly are promoted by zinc and implicate laminin zinc finger-like sequences. J Biol Chem 1996 Mar 22 ;271(12):6845-51.

Andberg MB, Hamberg M, Haeggstrom JZ. Mutation of tyrosine 383 in leukotriene A-4 hydrolase allows conversion of leukotriene A-4 into 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid: implications for the epoxide hydrolase mechanism. J Biol Chem 1997;272(37):23057-63.

Anderson KP, Kern CB, Crable SC, Lingrel JB. Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: identification of a new multigene family. Mol Cell Biol 1995 Nov ;15(11):5957-65.

Andreazzoli M, De Lucchini S, Costa M, Barsacchi G. RNA binding properties and evolutionary conservation of the Xenopus multifinger protein Xfin. Nucleic Acids Res 1993 Sep 11 ;21(18):4218-25.

Andrews GK, Kage K, Palmiter-Thomas P, Sarras MP Jr. Metal ions induce expression of metallothionein in pancreatic exocrine and endocrine cells. Pancreas 1990 Sep ;5(5):548-54.

Andrews JC, Nolan JP, Hammerstedt RH, Bavister BD. Characterization of N-(6-methoxy-8-quinolyl)-p-toluenesulfonamide for the detection of zinc in living sperm cells. Cytometry 1995;21(2):153-9.

Andrews JC, Nolan JP, Hammerstedt RH, Bavister BD. Role of zinc during hamster sperm capacitation. Biol Reprod 1994;51(6):1238-47.

Angela Nieto M, Sargent MG, Wilkinson DG, Cooke J. Control of cell behavior during vertebrate development by Slug, a zinc finger gene. Science 1994 May 6 ;264(5160):835-9.

Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P, Benarous R, Devoret R. Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein. Nucleic Acids Res 1991 Oct 11 ;19(19):5117-23.

Antonucci A, Di Baldassarre A, Di Giacomo F, Stuppia L, Palka G. Detection of apoptosis in peripheral blood cells of 31 subjects affected by Down syndrome before and after zinc therapy. Ultrastruct Pathol 1997 Sep-Oct;21(5):449-52.

Aoki H, Adams SL, Turner MA, Ganoza MC. Molecular characterization of the prokaryotic efp gene product involved in a peptidyltransferase reaction. Biochimie 1997;79(1):7-11.

Apezteguia I, Calligaris R, Bottardi S, Santoro C. Expression, purification, and functional characterization of the two zinc-finger domain of the human GATA-1. Protein Expr Purif 1994 Dec ;5(6):541-6.

Arakawa Y, Suzukik K. Metals and chrinic liver disease. Nihon Univ J Med 1992;34(3):109-26.

Arber S, Caroni P. Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. Genes Dev 1996 Feb 1 ;10(3):289-300.

Archambault J, Milne CA, Schappert KT, Baum B, Friesen JD, Segall J. The deduced sequence of the transcription factor TFIIIA from Saccharomyces cerevisiae reveals extensive divergence from Xenopus TFIIIA. J Biol Chem 1992 Feb 15 ;267(5):3282-8.

Archer TK, Hager GL, Omichinski JG. Sequence-specific DNA binding by glucocorticoid receptor "zinc finger peptides". Proc Natl Acad Sci U S A 1990 Oct ;87(19):7560-4.

Armstrong RC, Kim JG, Hudson LD. Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes. Glia 1995 Aug ;14(4):303-21.

Armstrong RC, Migneault A, Shegog ML, Kim JG, Hudson LD, Hessler RB. High-grade human brain tumors exhibit increased expression of myelin transcription factor 1 (MYT1), a zinc finger DNA-binding protein. J Neuropathol Exp Neurol 1997 Jul ;56(7):772-81.

Arora V, Iversen PL, Ebadi M. Manipulation of metallothionein expression in the regenerating rat liver using antisense oligonucleotides. Biochem Biophys Res Commun 1998 May 29 ;246(3):711-8.

Arranz V, Kress M, Ernoult-Lange M. The gene encoding the MOK-2 zinc-finger protein: characterization of its promoter and negative regulation by mouse Alu type-2 repetitive elements. Gene 1994 Nov 18 ;149(2):293-8.

Aruga J, Minowa O, Yaginuma H, Kuno J, Nagai T, Noda T, Mikoshiba K. Mouse Zic1 is involved in cerebellar development. J Neurosci 1998 Jan 1 ;18(1):284-93.

Aruga J, Yokota N, Hashimoto M, Furuichi T, Fukuda M, Mikoshiba K. A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem 1994 Nov ;63(5):1880-90.

Aruga J, Yozu A, Hayashizaki Y, Okazaki Y, Chapman VM, Mikoshiba K. Identification and characterization of Zic4, a new member of the mouse Zic gene family. Gene 1996 Jun 26 ;172(2):291-4.

Ashworth A, Denny P. Zinc finger protein genes in the mouse genome. Mamm Genome 1991;1(3):196-200.

Assmann S, Sigler K, Hofer M. Cd2+-induced damage to yeast plasma membrane and its alleviation by Zn2+: studies on Schizosaccharomyces pombe cells and reconstituted plasma membrane vesicles. Arch Microbiol 1996;165(4):279-84.

Attar RM, Gilman MZ. Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element. Mol Cell Biol 1992 May ;12(5):2432-43.

Aubry M, Demczuk S, Desmaze C, Aikem M, Aurias A, Julien JP, Rouleau GA. Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome. Hum Mol Genet 1993 Oct ;2(10):1583-7.

Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). Genomics 1992 Jul ;13(3):641-8.

Avery RA, Bettger WJ. Zinc deficiency alters the protein composition of the membrane skeleton but not the extractability or oligomeric form of spectrin in rat erythrocyte membranes. J Nutr 1992 Mar ;122(3):428-34.

Avunduk A M, Yardimci S, Avunduk M C, Kurnaz L, Kockar M C. Determinations of some trace and heavy metals in rat lenses after tobacco smoke exposure and their relationships to lens injury. Exp Eye Res 1997;65(3):417-23.

Azin F, Raie RM, Mahmoudi MM. Correlation between the levels of certain carcinogenic and anticarcinogenic trace elements and esophageal cancer in Northern Iran. Ecotoxicol Environ Safety 1998;39(3):179-84.

Azzini M, Girelli D, Olivieri O, Guarini P, Stanzial AM, Frigo A, Milanino R, Bambara LM, Corrocher R. Fatty acids and antioxidant micronutrients in psoriatic arthritis. J Rheumatol 1995 Jan ;22(1):103-8.

Baban S, Freeman JD, Mager DL. Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments. Genomics 1996 May 1 ;33(3):463-72.

Babenko HO, Zaviiskyi YM. [Effect of imuran on the activity of metalloenzymes and indices of metal metabolism in the organism]. Ukr Biokhim Zh 1996;68(4):113-6. (Ukr).

Babloyan AS, Karagezyan KG, Shakaryan MA, Ovsepyan LM, Simonyan MA. [Comparative study of the levels of blood metalloproteins during halothane anesthesia]. Anesteziol Reanimatolog 1997;(6):213. (Rus).

Back CJ, Sistonen L, Enkvist MO, Heikkila JE, Akerman KE. Ca2+ and Zn2+ dependence of DNA synthesis in untransformed and in Ha-ras(val-12)-expressing NIH 3T3 cells. Exp Cell Res 1993 Sep ;208(1):303-10.

Badenhorst P, Harrison S, Travers A. End of the line? Tramtrack and cell fate determination in Drosophila. Genes Cells 1996 Aug ;1(8):707-16.

Bagchi D, Vuchetich PJ, Bagchi M, Tran MX, Krohn RL, Ray SD, Stohs SJ. Protective effects of zinc salts on TPA-induced hepatic and brain lipid peroxidation, glutathione depletion, DNA damage and peritoneal macrophage activation in mice. Gen Pharmacol 1998 Jan ;30(1):43-50.

Baginski B. Alterations of the oxidative metabolism and other microbicidal activities of human polymorphonuclear leukocytes by zinc. Free Radic Res Commun 1990;10(4-5):227-35.

Bai C, Tolias PP. Cleavage of RNA hairpins mediated by a developmentally regulated CCCH zinc finger protein. Mol Cell Biol 1996 Dec ;16(12):6661-7.

Bailey LA, Ebbole DJ. The fluffy gene of Neurospora crassa encodes a Gal4p-type C6 zinc cluster protein required for conidial development. Genetics 1998 Apr ;148(4):1813-20.

Bain C, Green A, Siskind V, Alexander J, Harvey P. Diet and melanoma: an exploratory case-control study. Ann Epidemiol 1993 May;3(3):235-8.

Baird PN, Cowell JK. A novel zinc finger mutation in a patient with Denys-Drash syndrome. Hum Mol Genet 1993 Dec ;2(12):2193-4.

Baird TT Jr, Waheed A, Okuyama T, Sly WS, Fierke CA. Catalysis and inhibition of human carbonic anhydrase IV. Biochemistry 1997;36(9):2669-78.

Balkan ME, Ozgunes H. Serum protein and zinc levels in patients with thoracic empyema. Biol Trace Elem Res 1996 Aug ;54(2):105-12.

Ballatori N. Mechanisms of metal transport across liver cell plasma membranes. Drug Metab Rev 1991;23(1-2):83-132.

Banecki B, Liberek K, Wall D, Wawrzynow A, Georgopoulos C, Bertoli E, Tanfani F, Zylicz M. Structure-function analysis of the zinc finger region of the DnaJ molecular chaperone. J Biol Chem 1996 Jun 21 ;271(25):14840-8.

Barabino SM, Hubner W, Jenny A, Minvielle-Sebastia L, Keller W. The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins. Genes Dev 1997 Jul 1 ;11(13):1703-16.

Baramova EN, Shannon JD, Bjarnason JB, Gonias SL, Fox JW. Interaction of hemorrhagic metalloproteinases with human alpha 2-macroglobulin. Biochemistry 1990 Jan 30 ;29(4):1069-74.

Barlow PN, Luisi B, Milner A, Elliott M, Everett R. Structure of the C3HC4 domain by 1H-nuclear magnetic resonance spectroscopy. A new structural class of zinc-finger. J Mol Biol 1994 Mar 25 ;237(2):201-11.

Barnard ML, Robertson B, Watts BP Jr, Turrens JF. Role of nitric oxide and superoxide anion in spontaneous lung chemiluminescence. Am J Physiol 1997;272(2 Pt 1):L262-7.

Barnard RC, Pascall JC, Brown KD, McKay IA, Williams NS, Bustin SA. Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes. Nucleic Acids Res 1993 Jul 25 ;21(15):3580.

Baron BW, Desai M, Baber LJ, Paras L, Zhang Q, Sadhu A, Duguay S, Nucifora G, McKeithan TW, Zeleznik-Le N. BCL6 can repress transcription from the human immunodeficiency virus type I promoter/enhancer region. Genes Chromosomes Cancer 1997 May ;19(1):14-21.

Baron MH, Farrington SM. Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells. Mol Cell Biol 1994 May ;14(5):3108-14.

Bartels F, Bergel H, Bigalke H, Frevert J, Halpern J, Middlebrook J. Specific antibodies against the Zn(2+)-binding domain of clostridial neurotoxins restore exocytosis in chromaffin cells treated with tetanus or botulinum A neurotoxin. J Biol Chem 1994 Mar 18 ;269(11):8122-7.

Barthelemy I, Carramolino L, Gutierrez J, Barbero JL, Marquez G, Zaballos A. zhx-1: a novel mouse homeodomain protein containing two zinc-fingers and five homeodomains. Biochem Biophys Res Commun 1996 Jul 25 ;224(3):870-6.

Bashford CL. Membrane pores--from biology to track-etched membranes. Biosci Rep 1995 Dec ;15(6):553-65.

Bashford CL, Alder GM, Fulford LG, Korchev YE, Kovacs E, MacKinnon A, Pederzolli C, Pasternak CA. Pore formation by S. aureus alpha-toxin in liposomes and planar lipid bilayers: effects of nonelectrolytes. J Membr Biol 1996;150(1):37-45.

Baskaran R, Rao MR. Mammalian spermatid specific protein, TP2, is a zinc metalloprotein with two finger motifs. Biochem Biophys Res Commun 1991 Sep 30 ;179(3):1491-9.

Basson M, Horvitz HR. The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein. Genes Dev 1996 Aug 1 ;10(15):1953-65.

Bastard C, Deweindt C, Kerckaert JP, Lenormand B, Rossi A, Pezzella F, Fruchart C, Duval C, Monconduit M, Tilly H. LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 1994 May 1 ;83(9):2423-7.

Bastos R, Lin A, Enarson M, Burke B. Targeting and function in mRNA export of nuclear pore complex protein Nup153. J Cell Biol 1996 Sep ;134(5):1141-56.

Baum MK. Nutritional alterations in high-risk groups in relationship to HIV-1 disease progression. Nutrition 1996;12(2):124.

Bavoso A, Ostuni A, Battistuzzi G, Menabue L, Saladini M, Sola M. Metal ion binding to a zinc finger peptide containing the Cys-X2-Cys-X4-His-X4-Cys domain of a nucleic acid binding protein encoded by the Drosophila Fw-element. Biochem Biophys Res Commun 1998 Jan 14 ;242(2):385-9.

Beani JC, Richard MJ, Berthod F, Arnaud J, Amblard P, Favier A. Effects of 8-methoxypsoralen plus UVA radiation (PUVA) on glutathione peroxidase and lipid peroxide plasma levels in psoriasic patients. Eur J Dermatol 1994;4(6):480-4.

Becker-Andre M, Andre E, DeLamarter JF. Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences. Biochem Biophys Res Commun 1993 Aug 16 ;194(3):1371-9.

Becker KG, Canning RD, Nagle JW, Dehejia AM, Polymeropoulos MH, Lee IJ, Gado AM, Biddison WE, Drew PD. Molecular cloning and mapping of a novel developmentally regulated human C2H2-type zinc finger. Mamm Genome 1997 Apr ;8(4):287-9.

Becker KG, Lee IJ, Nagle JW, Canning RD, Gado AM, Torres R, Polymeropoulos MH, Massa PT, Biddison WE, Drew PD. C2H2-171: a novel human cDNA representing a developmentally regulated POZ domain/zinc finger protein preferentially expressed in brain. Int J Dev Neurosci 1997 Nov ;15(7):891-9.

Becker KG, Nagle JW, Canning RD, Biddison WE, Ozato K, Drew PD. Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. Hum Mol Genet 1995 Apr ;4(4):685-91.

Beckerle MC. Zyxin: zinc fingers at sites of cell adhesion. Bioessays 1997 Nov ;19(11):949-57.

Bedwal RS, Nair N, Mathur RS. Effects of zinc deficiency and toxicity on reproductive organs, pregnancy and lactation: a review. Trace Elem Med 1991;8(2):89-100.

Bedwal RS, Verma V, Sinha A, Dewan R, Katoch M. Histological and biochemical changes in the ovary and uterus of zinc deficient Sprague Dawley rats. Trace Elem Electrocytes 1995;12(2):95-108.

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ZINC AND THE CENTRAL NERVOUS SYSTEM

Aguilera AJ. Molecular genetic advances in neurodegenerative disorders. Clin Lab Med 1995;15(4):915-26.

Aiba K, Kimura M, Sakata S, Matsuda K, Kaneko M, Onosaka S, Yamaoka Y, Tamaki N. Cosinor analysis of feed intake cycle of rats fed a zinc-deficient diet and the effect of zinc supplementation. J Nutr Sci Vitaminol (Tokyo) 1997 Jun;43(3):327-43.

Ancsin JB, Kisilevsky R. Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A. J Biol Chem 1997 Jan 3 ;272(1):406-13.

Andrasi E, Farkas E, Scheibler H, Reffy A, Bezur L. Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer's disease. Arch Gerontol Geriatr 1995;21(1):89-97.

Araki S, Murata K, Yokoyama K, Uchida E. Auditory event-related potential (P300) in relation to peripheral nerve conduction in workers exposed to lead, zinc, and copper: effects of lead on cognitive function and central nervous system. Am J Ind Med 1992;21(4):539-47.

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Beher D, Hesse L, Masters CL, Multhaup G. Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J Biol Chem 1996 Jan 19 ;271(3):1613-20.

Bennett CP, McEwen LM, McEwen HC, Rose EL. The Shipley project: treating food allergy to prevent criminal behaviour in community settings. J Nutral Environ Med 1998;8(1):77-83.

Bergeron C, Petrunka C, Weyer L. Copper/zinc superoxide dismutase expression in the human central nervous system: correlation with selective neuronal vulnerability. Am J Pathol 1996;148(1):273-9.

Berr C, Richard MJ, Roussel AM, Bonithon-Kopp C. Systemic oxidative stress and cognitive performance in the population- based EVA study. Free Radic Biol Med 1998;24(7-8):1202-8.

Bidmon H-J, Kato K, Schleicher A, Witte OW, Zilles K. Transient increase of manganese-superoxide dismutase in remote brain ares focal photothrombotic cortical lesion. Stroke 1998;29(1):203-11.

Bidmon H-J, Oermann E, Schleicher A, Kato K, Kinscherf R, Buchkremer-Ratzmann I, Witte O W, Zilles K. Copper-zinc superoxide dismutase and isolectin B-4 binding are markers for associative and transhemispheric diaschisis induced by focal ischemia in rat cortex. Neurosci Lett 1997;228(3):163-6.

Blaauwgeers HG, Vianney de Jong JM, Verspaget HW, Van den Berg FM, Troost D. Enhanced superoxide dismutase-2 immunoreactivity of astrocytes and occasional neurons in amyotrophic lateral sclerosis. J Neurol Sci 1996;140(1-2):21-9.

Bobilya DJ, Guerin JL, Rowe DJ. Zinc transport across an in vitro blood-brain barrier model. J Trace Elem Exp Med 1997;10(1):9-18.

Bogumil R, Faller P, Binz P-A, Vasak M, Charnock JM, Garner CD. Structural characterization of Cu(I) and Zn(II) sites in neuronal-growth-inhibitory factor by extended X-ray absorption fine structure (EXAFS). Eur J Biochem 1998;255(1):172-7.

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Bondy SC, Guo SX. Effect of an NMDA receptor antagonist and a ganglioside GM1 derivative upon ethanol-induced modification of parameters of oxidative stress in several brain regions. Brain Res 1996;716(1-2):165-70.

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Brown AM, Tummolo DM, Rhodes KJ, Hofmann JR, Jacobsen JS, Sonnenberg-Reines J. Selective aggregation of endogenous beta-amyloid peptide and soluble amyloid precursor protein in cerebrospinal fluid by zinc. J Neurochem 1997 Sep ;69(3):1204-12.

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Browning JD, O'Dell BL. Zinc deficiency decreases the concentration of N-methyl-D-aspartate receptors in guinea pig cortical synaptic membranes. J Nutr 1995 Aug ;125(8):2083-9.

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Bush AI, Multhaup G, Moir RD, Williamson TG, Small DH, Rumble B, Pollwein P, Beyreuther K, Masters CL. A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. J Biol Chem 1993 Aug 5 ;268(22):16109-12.

Bush AI, Pettingell WH JR, de Paradis M, Tanzi RE, Wasco W. The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. J Biol Chem 1994 Oct 28 ;269(43):26618-21.

Bush AI, Pettingell WH Jr, Paradis MD, Tanzi RE. Modulation of A beta adhesiveness and secretase site cleavage by zinc. J Biol Chem 1994 Apr 22 ;269(16):12152-8.

Bush AI, Pettingell WH, Multhaup G, d Paradis M, Vonsattel JP, Gusella JF, Beyreuther K, Masters CL, Tanzi RE. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 1994 Sep 2;265(5177):1464-7. Comment in: Science 1994 Sep 2;265(5177):1365; Science 1995 Jun 30;268(5219):1920; discussion 1921-3.

Busselberg D, Platt B, Michael D, Carpenter DO, Haas HL. Mammalian voltage-activated calcium channel currents are blocked by Pb2+, Zn2+, and Al3+. J Neurophysiol 1994 Apr ;71(4):1491-7.

Cadet JL, Ladenheim B, Hirata H, Rothman RB, Ali S, Carlson E, Epstein C, Moran TH. Superoxide radicals mediate the biochemical effects of methylenedioxymethamphetamine (MDMA): evidence from using CuZn-superoxide dismutase transgenic mice. Synapse 1995;21(2):169-76.

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Canzoniero LM, Sensi SL, Choi DW. Measurement of intracellular free zinc in living neurons. Neurobiol Dis 1997;4(3-4):275-9.

Caporali MG, Bronzetti E, Ciriaco E, Niglio T, Ricci A, Scotti de Carolis A, Amenta F. Changes in the intensity of sulfide staining in fronto-parietal cortex of the rat following nucleus basalis magnocellularis lesions: possible relevance to Alzheimer's disease. Arch Gerontol Geriatr 1991 Sep-Oct;13(2):179-86.

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Chan PH. Role of oxidants in ischemic brain damage. Stroke 1996;27(6):1124-9.

Chan PH, Epstein CJ, Li Y, Huang TT, Carlson E, Kinouchi H, Yang G, Kamii H, Mikawa S, Kondo T, Copin J-C, Chen SF, Chan T, Gafni J, Gobbel G, Reola E. Transgenic mice and knockout mutants in the study of oxidative stress in brain injury. J Neurotrauma 1995;12(5):815-24.

Chan PH, Yang GY, Chen SF, Carlson E, Epstein CJ. Cold-induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-superoxide dismutase. Ann Neurol 1991;29(5):482-6.

Chang Y, Amin J, Weiss DS. Zinc is a mixed antagonist of homomeric rho 1 gamma-aminobutyric acid-activated channels. Mol Pharmacol 1995 Mar;47(3):595-602.

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Cheetham ME. Cell stress genes and chronic neurodegenerative disorders. Neuropathol Appl Neurobiol 1995;21(6):486-8.

Chen QX, Perkins KL, Wong RKS. Zn2+ blocks the NMDA- and Ca2+ -triggered postexposure current ipe in hippocampal pyramidal cells. J Neurophysiol 1998 Feb;79(2):1124-6.

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Choi DW, Koh JY. Zinc and brain injury. Annu Rev Neurosci 1998;21:347-75.

Chong YH, Suh YH. Amyloidogenic processing of Alzheimer's amyloid precursor protein in vitro and its modulation by metal ions and tacrine. Life Sci 1996;59(7):545-57.

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Constantinidis J. Treatment of Alzheimer's disease by zinc compounds. Drug Dev Res 1992;27(1):1-14.

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ZINC IN GROWTH AND SPECIFIC DISEASE ENTITIES

Zinc lozenges reduce the duration of common cold symptoms. Nutr Rev 1997 Mar ;55 (3):82-8.

Zinc: the missing link? J Am Optom Assoc 1997 Jul;68(7):463.

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CURRENT METHODS UTILIZED FOR ASSESSING ZINC

Diagnostic procedure on suspicion of zinc deficiency. Society for Minerals and Trace Elements. J Trace Elem Med Biol 1997 Apr;11(1):63.

Bartsch R, Klein D, Summer KH. The Cd-Chelex assay: a new sensitive method to determine metallothionein containing zinc and cadmium. Arch Toxicol 1990;64(3):177-80.

Cai M, Huang Y, Sakaguchi K, Clore GM, Gronenborn AM, Craigie R. An efficient and cost-effective isotope labeling protocol for proteins expressed in Escherichia coli. J Biomol NMR 1998;11(1):97-102.

Cicuttini FM, Martin M, Salvaris E, Ashman L, Begley CG, Novotny J, Maher D, Boyd AW. Support of human cord blood progenitor cells on human stromal cell lines transformed by SV40 large T antigen under the influence of an inducible (metallothionein) promoter. Blood 1992 Jul 1 ;80(1):102-12.

Cornelis R. Involvement of analytical chemistry in chemical speciation of metals in clinical samples. Ann Clin Lab Sci 1996;26(3):252-63.

Cousins RJ. Measurement of human metallothionein by enzyme-linked immunosorbent assay. Methods Enzymol 1991;205 :131-40.

Coyle P, Zalewski PD, Philcox JC, Forbes IJ, Ward AD, Lincoln SF, Mahadevan I, Rofe AM. Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc. Biochem J 1994 Nov 1;303(Pt 3):781-6.

Desjarlais JR, Berg JM. Length-encoded multiplex binding site determination: application to zinc finger proteins. Proc Natl Acad Sci U S A 1994 Nov 8 ;91(23):11099-103.

Desjarlais JR, Berg JM. Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins. Proc Natl Acad Sci U S A 1993 Mar 15 ;90(6):2256-60.

DiSilvestro RA, David C, David EA. Comparison of four indirect methods for fluid superoxide dismutase activities. Free Radic Biol Med 1990;9(6):507-10.

Elling CE, Thirstrup K, Nielsen SM, Hjorth SA, Schwartz TW. Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors. Ann N Y Acad Sci 1997 Apr 24 ;814:142-51.

Engel DW, Brouwer M. Crustaceans as models for metal metabolism: I. Effects of the molt cycle on blue crab metal metabolism and metallothionein. Mar Environ Res 1993;35(1-2):1-5.

Erusalimsky JD, John J, Hong Y, Moore M. A glass fiber/diethylaminoethyl double filter binding assay that measures apoptotic internucleosomal DNA fragmentation. Anal Biochem 1996;242(2):187-96.

Faure H, Favier A, Tripier M, Arnaud J. Determination of the major zinc fractions in human serum by ultrafiltration. Biol Trace Elem Res 1990 Dec ;24(1):25-37.

Friel JK, Longerich HP, Jackson SE. Determination of isotope ratios in human tissue enriched with zinc stable isotope tracers using inductively coupled plasma-mass spectrometry (ICP-MS). Biol Trace Elem Res 1993 May Jun;37(2-3):123-36.

Friel JK, Naake VL Jr, Miller LV, Fennessey PV, Hambidge KM. The analysis of stable isotopes in urine to determine the fractional absorption of zinc. Am J Clin Nutr 1992 Feb ;55(2):473-7.

Froom P, Kristal-Boneh E, Benbassat J, Ashkanazi R, Ribak J. Predictive value of determinations of zinc protoporphyrin for increased blood lead concentrations. Clin Chem 1998;44(6):1283-8.

Greisman HA, Pabo CO. A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science 1997 Jan 31 ;275(5300):657-61.

Grider A, Bailey LB, Cousins RJ. Erythrocyte metallothionein as an index of zinc status in humans. Proc Natl Acad Sci U S A 1990 Feb ;87(4):1259-62.

Guiraud P, Lepee M, Monjo AM, Richard MJ, Favier A. Cultured human skin fibroblasts absorb 65Zn. Optimization of the method and study of the mechanisms involved. Biol Trace Elem Res 1992 Jan-Mar ;32 :213-25.

Harraki B, Guiraud P, Rochat MH, Fussellier M, Favier A. Influence of copper, iron, and zinc on the physicochemical properties of parenteral admixture. J Parenter Sci Technol 1993 Sep-Oct ;47(5):199-204.

Hathout Y, Fabris D, Han MS, Sowder RC 2nd, Henderson LE, Fenselau C. Characterization of intermediates in the oxidation of zinc fingers in human immunodeficiency virus type 1 nucleocapsid protein P7. Drug Metab Dispos 1996 Dec ;24(12):1395-400.

Hazuda DJ, Wolfe AL, Hastings JC, Robbins HL, Graham PL, LaFemina RL, Emini EA. Viral long terminal repeat substrate binding characteristics of the human immunodeficiency virus type 1 integrase. J Biol Chem 1994 Feb 11 ;269(6):3999-4004.

He B, Zhang T, Zhou HM. Comparison of inactivation and conformational changes of aminoacylase during denaturation in lithium dodecylsulphate solutions. Int J Biol Macromol 1997 Feb ;20(1):53-62.

He B, Zhang Y, Zhang T, Wang HR, Zhou HM. Inactivation and unfolding of aminoacylase during denaturation in sodium dodecyl sulfate solutions. J Protein Chem 1995 Jul ;14(5):349-57.

Hocquellet P, L'Hotellier MD. Bioavailability and speciation of mineral micronutrients: the enzymolysis approach. J AOAC Int 1997 Jul-Aug;80(4):920-927.

Hong Z, Hambidge KM. [Zinc metabolic pool size: a reliable index for the assessment of zinc nutriture]. Acta Nutr Sinica 1993;15(2):169-74. (Chi).

House WA, Apgar J, Smith JC. The gerbil: a model for studying the metabolism of beta-carotene and minerals. Nutr Res 1997;17(8):1293-302.

Howell GA, Frederickson CJ. A retrograde transport method for mapping zinc-containing fiber systems in the brain. Brain Res 1990 May 7;515(1-2):277-86.

Hueber AO, Pierres M, He HT. Quantitating apoptosis by a nonradioactive DNA dot blot assay. Anal Biochem 1994 Sep ;221(2):431-3.

Jayawickreme CK, Chatt A. Studies on zinc- and cadmium-bound proteins in bovine kidneys by biochemical and neutron activation techniques. Biol Trace Elem Res 1990 Jul-Dec ;26-27 :503-12.

Ji H, Zhang R, Lai L, Shao M. Solid-phase synthesis, metal binding and folding properties of caulimovirus-related 'zinc finger'. Int J Pept Protein Res 1996 Nov ;48(5):461-4.

King JC, Lowe NM, Jackson MJ, Shames DM. The double isotope tracer method is a reliable measure of fractional zinc absorption [letter]. Eur J Clin Nutr 1997 Nov;51(11):787-8.

Klein D, Sato S, Summer KH. Quantification of oxidized metallothionein in biological material by a Cd saturation method. Anal Biochem 1994 Sep ;221(2):405-9.

Knudsen E, Jensen M, Solgaard P, Sorensen SS, Sandstrom B. Zinc absorption estimated by fecal monitoring of zinc stable isotopes validated by comparison with whole-body retention of zinc radioisotopes in humans. J Nutr 1995 May;125(5):1274-82.

Kothekar V. Computer simulation of zinc finger motifs from cellular nucleic acid binding protein and their interaction with consensus DNA sequences. FEBS Lett 1990 Nov 12 ;274(1-2):217-22.

Krebs NF, Miller LV, Naake VL, Lei S, Westcott JE, Fennessey PV, Hambidge KM. The use of stable isotope techniques to assess zinc metabolism. J Nutral Biochem 1995;6(6):292-301.

Leone M, Cupane A, Militello V, Stroppolo ME, Desideri A. Fourier transform infrared analysis of the interaction of azide with the active site of oxidized and reduced bovine Cu,Zn superoxide dismutase. Biochemistry 1998;37(13):4459-64.

Liu Q, Segal DJ, Ghiara JB, Barbas CF 3rd. Design of polydactyl zinc-finger proteins for unique addressing within complex genomes. Proc Natl Acad Sci U S A 1997 May 27 ;94(11):5525-30.

Louie AY, Meade TJ. A cobalt complex that selectively disrupts the structure and function of zinc fingers. Proc Natl Acad Sci U S A 1998 Jun 9 ;95(12):6663-8.

Lowe NM, Shames DM, Woodhouse LR, Matel JS, Roehl R, Saccomani MP, Toffolo G, Cobelli C, King JC. A compartmental model of zinc metabolism in healthy women using oral and intravenous stable isotope tracers. Am J Clin Nutr 1997 Jun;65(6):1810-9.

lvkovic-Jensen MM, Kostic NM. Effects of viscosity and temperature on the kinetics of the electron- transfer reaction between the triplet state of zinc cytochrome c and cupriplastocyanin. Biochemistry 1997;36(26):8135-44.

Miller LV, Hambidge KM, Fennessey PV. Analytical considerations in trace metal isotope analysis using fast atom bombardment-induced ionization. Anal Chim Acta 1990;241(2):249-54.

Miller LV, Hambidge KM, Naake VL, Hong Z, Westcott JL, Fennessey PV. Size of the zinc pools that exchange rapidly with plasma zinc in humans: alternative techniques for measuring and relation to dietary zinc intake. J Nutr 1994 Feb ;124(2):268-76.

Mori S, Abeygunawardana C, van Zijl PC, Berg JM. Water exchange filter with improved sensitivity (WEX II) to study solvent-exchangeable protons. Application to the consensus zinc finger peptide CP-1. J Magn Reson B 1996 Jan ;110(1):96-101.

Nishiguchi K, Ishida K, Nakajima M, Maeda T, Komada F, Iwakawa S, Tanigawara Y, Okumura K. Effects of transfection with the Cu, Zn-superoxide dismutase gene on xanthine-xanthine oxidase-induced cytotoxicity in fibroblasts from rat skin. Pharm Res (New York) 1996;13(4):577-82.

Olson LP, Luo J, Almarsson O, Bruice TC. Mechanism of aldehyde oxidation catalyzed by horse liver alcohol dehydrogenase. Biochemistry 1996 Jul 30 ;35(30):9782-91.

Paci M, Desideri A, Sette M, Ciriolo MR, Rotilio G. Assignment of imidazole resonances from two-dimensional proton NMR spectra of bovine Cu,Zn superoxide dismutase. Evidence for similar active site conformation in the oxidized and reduced enzyme. FEBS Lett 1990 Apr 9;263(1):127-30.

Pattison SE, Telles S, Friar S, Stowell C, Beckley R. Zinc diffusion through lipid bilayers. Arch Biochem Biophys 1998 Mar 1;351(1):41-6.

Pellegrino GR, Berg JM. Identification and characterization of "zinc-finger" domains by the polymerase chain reaction. Proc Natl Acad Sci U S A 1991 Jan 15;88(2):671-5.

Rebar EJ, Greisman HA, Pabo CO. Phage display methods for selecting zinc finger proteins with novel DNA-binding specificities. Methods Enzymol 1996;267:129-49.

Schuette SA, Janghorbani M, Young VR, Weaver CM. Dysprosium as a nonabsorbable marker for studies of mineral absorption with stable isotope tracers in human subjects. J Am Coll Nutr 1993 Jun;12(3):307-15.

SoLtyk K, Lozak A, Wyszecka E, Fijaek Z. Determination of zinc, magnesium and calcium in therapeutical nutrients by flameless AAS after microwave digestion. Acta Pol Pharm 1995 Nov-Dec;52(6):437-40.

Suhy DA, O'Halloran TV. Metal-responsive gene regulation and the zinc metalloregulatory model. Met Ions Biol Syst 1996;32:557-78.

Thompson RB, Patchan MW. Lifetime-based fluorescence energy transfer biosensing of zinc. Anal Biochem 1995 May 1;227(1):123-8.

Tiran B, Lorenz O, Tiran A, Buchinger W, Eber O. Comparison of direct versus indirect determination of zinc concentration in erythrocytes in euthyroid and hyperthyroid subjects. Eur J Clin Chem Clin Biochem 1993 Apr;31(4):239-44.

Van den Berg GJ, Wolterbeek HT, De Goeij JJM, Beynen AC. Absorption and retention studies of trace elements and minerals in rats using radiotracers and whole-body counting. Lab Anim 1995;29(1):66-77.

van Remmen H, Williams MD, Heydari AR, Takahashi R, Chung HY, Yu BP, Richardson A. Expression of genes coding for antioxidant enzymes and heat shock proteins is altered in primary cultures of rat hepatocytes. J Cell Physiol 1996;166(2):453-60.

Van Wouwe JP, Waser I. Comparison between total and ultrafiltrable serum zinc as test to diagnose zinc deficiency in infants and children. Biol Trace Elem Res 1994 Mar;40(3):203-11.

Wang J, Luo QH, Zhang JJ, Shen MC, Liu AD, Gu HC, Li FM, Di SJ. A pulse radiolysis study of the catalytic dismutation of superoxide ion by a superoxide dismutase model compound (C(aptn))(ClO4)2. Radiat Physics Chem 1997;49(5):527-30.

Wastney ME, Subramanian KN, Broering N, Boston R. Using models to explore whole-body metabolism and accessing models through a model library. Metabolism 1997 Mar;46(3):330-2.

Yergey AL. Issues in constant tracer infusion and mineral metabolism. Adv Exp Med Biol 1994;352:279-90.

Yu X, Wojciechowski M, Fenselau C. Assessment of metals in reconstituted metallothioneins by electrospray mass spectrometry. Anal Chem 1993 May 15 ;65(10):1355-9.

Zalewski PD, Millard SH, Forbes IJ, Kapaniris O, Slavotinek A, Betts WH, Ward AD, Lincoln SF, Mahadevan I. Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc. J Histochem Cytochem 1994 Jul;42(7):877-84.

Zhou JS, Hoffman BM. Stern-volmer in reverse: 2:1 stoichiometry of the cytochrome c-cytochrome c peroxidase electron-transfer complex. Science 1994 Sep 16;265(5179):1693-6.

Zhou JS, Kostic NM. Comparison of electrostatic interactions and of protein-protein orientations in electron-transfer reactions of plastocyanin with the triplet state of zinc cytochrome c and with zinc cytochrome c cation radical. Biochemistry 1993;32(17):4539-46.

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First published: 02 November 1998
Last updated: 02 November 1998
Date Archived: 31 August 2004
Metadata | Permanence level: Permanent: Stable Content


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Last updated: 02 November 1998