Project Number: 1235-52530-051-00
Project Type: Appropriated

Start Date: Oct 01, 2004
End Date: Mar 15, 2009

Objective:
1) To synthesize N-coumaroyltyramine and its analogues and to identify their cellular effects and molecular mechanisms, particularly as related to cancer modulation, 2) To assess anti-cancer and other health effects N-coumaroyltyramine and its analogues in an animal model.

Approach:
1. Synthesis of phenylpropenic acid conjugates (N-coumaroyltyramine and its analogues). 2. Measurement of phenylpropenic acid conjugates in cell and biological samples. 3. Investigation of effects of phenylpropenic acid conjugates on cell cycle and growth of cancer cells. 4. Apoptosis study. 5. Hydrogen peroxide quenching study. 6. Investigation of effects of phenylpropenic acid conjugates on MAPK Kinases. 7. Investigation of effects of phenylpropenic acid conjugates on protein tyrosine kinase including EGFR. 8. Investigation of effects of phenylpropenic acid conjugates on xenograft tumor in nude mice.