You are here:
Considerations For Developing A Dosimetry-Based Cumulative Risk Assessment Approach For Mixtures of Environmental Contaminants (Final Report)
Citation:
U.S. EPA. Considerations For Developing A Dosimetry-Based Cumulative Risk Assessment Approach For Mixtures of Environmental Contaminants (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-07/064, 2007.
Impact/Purpose:
This report develops a framework to guide decisions whether to incorporate physiologically-based pharmacokinetic (PBPK) modeling into the cumulative risk assessment process.
Description:
EPA announced the availability of the final report, Considerations for Developing a Dosimetry-Based Cumulative Risk Assessment Approach for Mixtures of Environmental Contaminants. This report describes a process that can be used to determine the potential value of developing physiologically based pharmacokinetic (PBPK) modeling to support a cumulative risk assessment. It also addresses the justification for developing physiologically based pharmacokinetic (PBPK) models for cumulative risk assessment. Chemical interactions in the body can alter the response observed, but the likelihood of an interactions is often most dependent on exposure. Results from these models can explain the basis for chemical interactions and can predict their likelihood at low, environmental exposures. This report identifies some key points to be considered when deciding whether to use PBPK modeling in a cumulative risk assessment.
URLs/Downloads:
U.S. EPA/Considerations for Developing a Dosimetry-Based Cumulative Risk Assessment Approach for Mixtures of Environmental Contaminants (Final Report) (PDF, 77 pp, 610 KB, about PDF)Appendix A: PHYSIOLOGICALLY-BASED PHARMACOKINETIC/PHARMACODYNAMIC (PBPK/PD) MODELING REFERENCE (PDF, 16 pp, 528 KB, about PDF)
Appendix B: HOW TO INCORPORATE CREDIBLE HUMAN ENZYME STUDIES INTO THE PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODELING AND RISK ASSESSMENT PROCESS Reference (PDF, 19 pp, 1233 KB, about PDF)
Appendix C: INFORMATION ON CHEMICAL MIXTURES AND THEIR COMPONENT CHEMICALS (PDF, 86 pp, 1018 KB, about PDF)
Appendix D: Method of Analysis to Perform a Tissue-Based Cumulative Risk Assessment for Mixtures of Chemicals (PDF, 22 pp, 259 KB, about PDF)
EPA Guidance on Cumulative Risk Assessment of Pesticide Chemicals that Have a Common Mechanism of Toxicity
WHO. 2010. Characterization and Application of PBPK Models in Risk Assessment (Final Report)
