NIDA Research Monograph, Number 147 [Printed in 1995]
If you have the Acrobat reader plug-in for Netscape or Internet Explorer click on the document link and you will be able
to view and/or print out the pages. If you have trouble viewing the document in your browser window, download the document (Windows users - right click on the link and Save as...) to your computer and get Adobe Acrobat Reader (free) in order to view it.
This monograph is not available by chapter. The Table of Contents (below) is shown to assist in locating information prior to downloading the monograph.
Download Monograph147.pdf - Discovery of Novel Opioid Medications (2.1 MB)
Table of Contents
Introduction-----v
Rao S. Rapaka and Heinz Sorer
Targeting Drugs to the Brain by Sequential Metabolism-----1
Nicholas Bodor
Action of Opioid Drugs on the Brain-Reward System-----33
Conan Kornetsky
Drugs That Modify Opioid Tolerance, Physical Dependence, and Abstinence Symptoms: Preclinical and Clinical Studies-----53
Hemendra N. Bhargava
Future Directions in the Pharmacological Management of Hyperalgesic and Allodynic Pain States: The NMDA Receptor-----84
Tony L. Yaksh, Sandra R. Chaplan, and Annika B. Malmberg
Dual Inhibitors of Enkephalin-Degrading Enzymes (Neutral Endopeptidase 24.11 and Aminopeptidase N) as Potential New Medications in the Management of Pain and Opioid Addiction-----104
Bernard P. Rogues and Florence Noble
Enhanced N-Methyl-D-Aspartate (NMDA)-Induced Activity Following Morphine: Sensitivity to Sigma and PCP Ligands-----146
Alice A. Larson, Rustam Yu. Yukhananov, and Julie S. Kreeger
Dynorphin A: A Rectifying Peptide-----161
Nancy M. Lee
Inhibitors of Nitric Oxide Synthase and the Opioid Withdrawal Syndrome-----170
Edythe D. London, Alane S. Kimes, and D. Bruce Vaupel
Nitric Oxide and Opioid Tolerance-----182
Gavril W. Pasternak
Methoclocinnamox: A µ Partial Agonist With Pharmacotherapeutic Potential for Heroin Abuse-----195
James H. Woods, John W. Lewis, Gail Winger, Eduardo Butelman, Jillian Broadbear, and Gerald Zernig
ACEA-1011, a Novel NMDA Receptor/Glycine Site Antagonist, Produces Antinociception but Not Tolerance in the Formalin Test in Mice-----220
Kabirullah Lutfy, John F. W. Keana, and Eckard Weber
Etorphine Elicits Unique Inhibitory-Agonist and Excitatory-Antagonist
Actions at Opioid Receptors on Sensory Neurons: New Rationale for
Improved Clinical Analgesia and Treatment of Opiate Addiction-----234
Stanley M. Crain and Ke-Fei Shen
The Association of Neuropathic Pain, Morphine Tolerance and Dependence, and the Translocation of Protein Kinase C-----269
David J. Mayer, Jianren Mao, and Donald D. Price
|