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Protein crystal growth in low gravityThe effect of low gravity on the growth of protein crystals and those parameters which will affect growth and crystal quality was studied. The proper design of the flight hardware and experimental protocols are highly dependent on understanding the factors which influence the nucleation and growth of crystals of biological macromolecules. Thus, those factors are investigated and the body of knowledge which has been built up for small molecule crystallization. These data also provide a basis of comparison for the results obtained from low-g experiments. The flows around growing crystals are detailed. The preliminary study of the growth of isocitrate lyase, the crystal morphologies found and the preliminary x ray results are discussed. The design of two apparatus for protein crystal growth by temperature control are presented along with preliminary results.
Document ID
19900017347
Acquisition Source
Legacy CDMS
Document Type
Contractor Report (CR)
Authors
Feigelson, Robert S.
(Stanford Univ. CA, United States)
Date Acquired
September 6, 2013
Publication Date
June 1, 1990
Subject Category
Solid-State Physics
Report/Patent Number
SU-CMR-90-5
NASA-CR-186243
NAS 1.26:186243
Accession Number
90N26663
Funding Number(s)
CONTRACT_GRANT: NAG8-774
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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