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| Table of Contents Series Note PDF Version of This CBM Sample Citations Introduction Bibliography: Behavioral/Social/Cultural Factors Herbs, Botanicals, and Phytochemicals
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January 1997 through October 2002 3445 Citations Prepared by
2003 January U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Library of
Medicine Each bibliography in the Current Bibliographies in Medicine (CBM) series covers a distinct subject area of biomedicine and fulfills a current awareness function. Online databases and the Internet are the primary sources for citations in these bibliographies. Relevance to the subject is the only criterion for inclusion of works in a CBM; the format, ownership, or location of the material are not considered. Other publications in the Current Bibliographies in Medicine series are available through the Library's World Wide Web site at pubs/resources.html Comments and suggestions on this series may be addressed to: Karen Patrias, Editor PubMed®, LocatorPlus®, and the NLM Gateway The Library offers three interfaces to its databases; all are available on the World Wide Web. PubMed provides access primarily to the journal literature; LocatorPlus is an online catalog of the books, journal titles, and audiovisuals held by the Library; and the NLM Gateway serves as an entry point for a variety of databases and other Library products. Further information on PubMed, LocatorPlus, and the NLM Gateway may be found at http://www.nlm.nih.gov/nlmhome.html. The Portable Document Format (PDF) version of this bibliography will soon be available from elderdietsuppl.pdf. Note that PDF documents require the use of the Adobe® Acrobat® Reader, which may be downloaded from the Adobe Web site at no charge. Citations are formatted according to the rules established for Index Medicus®*. Sample journal and dissertation citations appear below. For journal articles written in a foreign language, the English translation of the title displays in brackets; for monographs and audiovisuals the title is given in the original language. In all cases the three-letter abbreviation for the language of publication appears at the end of the citation. An availability statement follows many journal article citations. This statement contains an Internet hyperlink to the citation in the NLM PubMed retrieval system. The PubMed record includes an abstract for most articles and may also provide a link to the publisher's Internet site. Journal Article: Example: Order, with separating punctuation: Dissertation: Example:Rawson ES. Creatine supplementation in older men [dissertation]. Amherst (MA): University of Massachusetts; 2000. 222 p. Order, with separating punctuation: Patrias, Karen. National Library of Medicine recommended formats for bibliographic citation. Bethesda (MD): The Library; 1991 Apr. Available from: NTIS, Springfield, VA; PB91-182030. Patrias, Karen. National Library of Medicine recommended formats for bibliographic citation. Supplement: Internet formats. Bethesda (MD): The Library; 2001 Jul. Available from: pubs/formats/internet.pdf |
Dietary Supplement Use in the Elderly
In the last twenty years there has been increased recognition of the direct relationship between diet and health. Gerontologists and nutritionists are now more interested in the level of a nutrient that it takes to prevent and/or manage a chronic disease state rather than the level of a nutrient needed to prevent a deficiency disease state. In terms of nutritional needs, the elderly population is one of the most diverse and heterogeneous of any age group. Determining the nutritional needs of older adults is challenging because their physiology, medical conditions, lifestyles, and social situations are different from those of younger people.
The use of dietary supplements has increased dramatically as our knowledge about the role of nutrients and other bioactive components of food in health has increased. Much of the information about the diet and health connection that has driven this trend is related to the reduction of chronic disease risk in adults. Belief in the use of these substances for health enhancement and disease prevention has been particularly evident among the elderly. The National Institutes of Health (NIH), along with other government agencies such as the US Department of Agriculture (USDA), the Food and Drug Administration (FDA), and the Centers for Disease Control and Prevention (CDC), have had a keen interest in expanding our knowledge about: (1) the bioavailability of nutrients and other bioactive components of dietary supplements; (2) the identification of critical gaps in our knowledge about the use of dietary supplements in the elderly; and (3) mechanisms of action whereby dietary supplements might delay aging, facilitate health, and prevent the progression of diseases of the elderly.
Dietary supplements encompass a wide range of products, including vitamins, minerals, amino acids, herbs, and other botanicals. The amount of scientific data available on the safety and efficacy of dietary supplements varies enormously, ranging from folklore to facts. For some supplements, recommended levels for the elderly have been established through extensive research and are published, but for others, serious negative health consequences can occur, especially in relation to interactions with prescription medications.
As the third in a series of conferences focusing on dietary supplement use throughout the lifespan*, the NIH Office of Dietary Supplements and the National Institutes of Aging organized this conference titled Dietary Supplement Use in the Elderly, held on January 14-15, 2003, in Bethesda, Maryland. Cosponsors of the workshop included the Office of Behavioral and Social Sciences Research, the National Center for Complementary and Alternative Medicine, the National Cancer Institute, the National Eye Institute, and the National Institute for Neurological Diseases and Stroke at the NIH, and the USDA. The goals of the conference were to review the current status of the science related to dietary supplement use in the elderly. The outcomes of the conference will help guide the NIH in the development of future research initiatives in this area.
Consistent with themes developed during previous NIH workshops on dietary supplement use, the agenda of this conference included discussions of four key topical areas from a developmental and methodological perspective. The thematic topics include:
This bibliography, which was produced in support of the conference, provides a subject arrangement of citations to journal articles, technical reports, and dissertations that contain information in the field of dietary supplements and health in the elderly. It has been divided into thirteen sections and includes: (1) an overview of nutrition, physiology, and the aging process; (2) patterns of supplement use; (3) surveys of products and use; (4) behavioral, social, and cultural factors; (5) interactions of supplements with drugs, foods, and other supplements; (6) assessment methodologies; (7) herbs, botanicals, and phytochemicals; (8) vitamins and antioxidants; (9) hormone products, (10) amino acids and proteins; (11) minerals; (12) dietary fats; and (13) other types of supplements, such as probiotics and coenzyme Q10. In the first six sections, the citations have been arranged alphabetically by author name. Sections seven through thirteen have been ordered first by area of the body or function that they affect, then alphabetically by author. A citation may appear in more than one category. For example: references on β-carotene may be found both under "Vitamins and Antioxidants" and "Herbs, Botanicals, and Phytochemicals." Also included within the category of "Herbs, Botanicals, and Phytochemicals" are bioactive compounds such as the flavonoids, phytoestrogens, plant sterols, and plant stanols. Dietary fiber constituents are also included in this category.
Because the literature is extensive, this bibliography is necessarily selective. Preference has been given to reports of controlled trials, reviews, case series, and dissertations dealing with populations aged 50 and older that were published in English or which have English abstracts. Results of studies reporting both benefits and risks associated with the use of dietary supplements have been included. Observational diet studies have been included if they provided information on dietary supplements or if they provided background information or added perspective regarding the levels of consumption of important nutrients and/or bioactive compounds. It was not the focus of this bibliography to include citations whereby dietary supplements were administered to the acutely ill or provided by means other than oral intake.
The compilers wish to thank Oluchi Ukaegbu and Phyllis Levine for their technical assistance in editing this bibliography.
*Please refer to the ODS homepage http://dietary-supplements.info.nih.gov/ for information regarding the preceding conferences in the lifespan series: "Dietary Supplement Use in Children: Who, What, Why, and Where Do We Go From Here?" held February 12-13, 2001, and "Dietary Supplement Use in Women: Current Status and Future Directions" held January 28-29, 2002.
This publication is not copyrighted and may be freely reproduced. However any reproductions of this bibliography, in whole or in part, should include all credits. If you wish to cite this bibliography, the correct format is:
Patrias, Karen; Slack, Kathy; Costello, Rebecca B.; Chamot, Judith, compilers. Dietary supplement use in the elderly [bibliography on the Internet]. Bethesda (MD): National Library of Medicine (US); 2003 Jan [insert cited year month day in brackets]. [insert no. of screens or lines in brackets]. (Current bibliographies in medicine; no. 2003-1). 3445 citations from January 1997 through October 2002. Available from: elderdietsuppl.html
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Akner G, Cederholm T. Treatment of protein-energy malnutrition in chronic nonmalignant disorders. Am J Clin Nutr. 2001 Jul;74(1):6-24. Available from: PubMed; PMID 11451713
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Ames BN. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res. 2001 Apr 18;475(1-2):7-20. Available from: PubMed; PMID 11295149
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Anti-aging products, Part I. Can supplements rewind our body clocks? Harv Womens Health Watch. 2001 Nov;9(4):2-3. Available from: PubMed; PMID 11724707
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Austad SN. Why we age: what science is discovering about the body's journey through life. New York: J. Wiley & Sons; 1997. 256.
Bashir S, Lipman TO. Nutrition in gastroenterology and hepatology. Prim Care. 2001 Sep;28(3):629-45. Available from: PubMed; PMID 11483448
Bates CJ, Prentice A, Cole TJ, Van der Pols JC, Doyle W, Finch S, Smithers G, Clarke PC. Micronutrients: Highlights and research challenges from the 1994-5 National Diet and Nutrition Survey of people aged 65 years and over. Br J Nutr. 1999;82(1):7-15. Available from: PubMed; PMID 10655951
Beal MF. Mitochondrial dysfunction in neurodegenerative diseases. Biochim Biophys Acta. 1998 Aug 10;1366(1-2):211-23. Available from: PubMed; PMID 9714810
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Beatty S, Koh H-H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000 Sep-Oct;45(2):115-34. Available from: PubMed; PMID 11033038
Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998 Apr;78(2):547-81. Available from: PubMed; PMID 9562038
Beilin LJ, Burke V, Cox KL, Hodgson JM, Mori TA, Puddey IB. Non pharmacologic therapy and lifestyle factors in hypertension. Blood Press. 2001;10(5-6):352-65.
Bendich A. Micronutrients in women's health and immune function. Nutrition. 2001 Oct;17(10):858-67. Available from: PubMed; PMID 11684393
Bengmark S. Nutritional modulation of acute- and 'chronic'-phase responses. Nutrition. 2001 Jun;17(6):489-5. Available from: PubMed; PMID 11434344
Berr C, Balansard B, Arnaud J, Roussel AM, Alperovitch A. Cognitive decline is associated with systemic oxidative stress: the EVA study. Etude du Vieillissement Arteriel. J Am Geriatr Soc. 2000 Oct;48(10):1285-91. Available from: PubMed; PMID 11037017
Braccio L, Camparini M, Graziosi P, Baratta G, Ferrigno L, Williams SL, Rosmini F, Sperduto R D, Maraini G. An independent evaluation of the Age-Related Eye Disease Study(AREDS) cataract grading system. Curr Eye Res. 1998 Jan;17(1):53-9. Available from: PubMed; PMID 9472471
Brickey M. Defy aging: develop the mental and emotional vitality to live longer, healthier and happier than you ever imagined. Columbus(OH): New Resources Press; 2000. 395.
Brown NA, Bron AJ, Harding JJ, Dewar HM. Nutrition supplements and the eye. Eye. 1998;12( Pt 1):127-33. Available from: PubMed; PMID 9614529
Butler RN, Fossel M, Harman SM, Heward CB, Olshansky SJ, Perls TT, Rothman DJ, Rothman SM, Warner HR, West MD, Wright WE. Is there an antiaging medicine? J Gerontol A Biol Sci Med Sci. 2002 Sep;57(9):B333-8. Available from: PubMed; PMID 12196485
Butler RN, Fossel M, Pan CX, Rothman DJ, Rothman SM. Anti-aging medicine. 2. Efficacy and safety of hormones and antioxidants. Geriatrics. 2000 Jul;55(7):48-52, 55-6, 58. Available from: PubMed; PMID 10909406
Cantuti-Castelvetri I, Shukitt-Hale B, Joseph JA. Neurobehavioral aspects of antioxidants in aging. Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):367-81. Available from: PubMed; PMID 10817921
Castle SC. Impact of age-related immune dysfunction on risk of infections. Z Gerontol Geriatr. 2000 Oct;33(5):341-9. Available from: PubMed; PMID 11130187
Chan JM, Stampfer MJ, Giovannucci EL. What causes prostate cancer? A brief summary of the epidemiology. Semin Cancer Biol. 1998;8(4):263-73.
Chandra RK. Nutrition and immunology: from the clinic to cellular biology and back again. Proc Nutr Soc. 1999 Aug;58(3):681-3. Available from: PubMed; PMID 10604203
Chandra RK. Nutrition and the immune system: an introduction. Am J Clin Nutr. 1997 Aug;66(2):460S-3S. Available from: PubMed; PMID 9250133
Chavez ML, Chavez PI. Ginkgo(Part 2): clinical efficacy, dosage, and adverse effects. Hosp Pharm. 1998;33(9):1076-95.
Chernoff R. Food and nutrition services for the elderly. Health Care Food Nutr Focus. 1998 Jun;14(10):5-9. Available from: PubMed; PMID 10181401
Chernoff R. Nutrition and health promotion in older adults. J Gerontol A Biol Sci Med Sci. 2001 Oct;56 Spec No 2(2):47-53. Available from: PubMed; PMID 11730237
Christen WG, Gaziano JM, Hennekens CH. Design of Physicians' Health Study II--a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials. Ann Epidemiol. 2000 Feb;10(2):125-34. Available from: PubMed; PMID 10691066
Cokolic M. Diabetes mellitus and osteoporosis. Diabetol Croat. 1998;27(4):135-42.
Corcoran ME. Polypharmacy in the older patient with cancer. Cancer Control. 1997 Oct;4(5):419-28. Available from: PubMed; PMID 10763050
Cras P. Recent developments in Alzheimer's disease. Acta Clin Belg. 2001 Sep-Oct;56(5):269-78. Available from: PubMed; PMID 11770221
Creamer P, Flores R, Hochberg MC. Management of osteoarthritis in older adults. Clin Geriatr Med. 1998 Aug;14(3):435-54. Available from: PubMed; PMID 9664101
Daniel E . Age-related macular degeneration: a review for health educators. Am J Health Educ. 2002 Mar-Apr;33(2):109-14.
Das A. Prevention of visual loss in older adults. Clin Geriatr Med. 1999 Feb;15(1):131-44, vii. Available from: PubMed; PMID 9855663
Davis WM. Antiaging products and tactics. Drug Topics. 1997;141(4):92-101.
Deal CL. Osteoporosis: prevention, diagnosis, and management. Am J Med. 1997 Jan 27;102(1A):35S-9S. Available from: PubMed; PMID 9217558
Delmas PD. Treatment of postmenopausal osteoporosis. Lancet. 2002 Jun 8;359(9322):2018-26. Available from: PubMed; PMID 12076571
Deschamps V, Barberger-Gateau P, Peuchant E, Orgogozo JM. Nutritional factors in cerebral aging and dementia: epidemiological arguments for a role of oxidative stress. Neuroepidemiology. 2001 Feb;20(1):7-15. Available from: PubMed; PMID 11174040
Dietary supplements reduce risk of vision loss from age-related macular degeneration. Optom Vis Sci. 2001 Dec;78(12):856. Available from: PubMed; PMID 11780662
Dror Y, Stern F, Berner YN, Kaufmann NA, Berry E, Maaravi Y, Altman H , Cohen A, Leventhal A, Kaluski DN. [Micronutrient(vitamins and minerals) supplementation for the elderly, suggested by a special committee nominated by Ministry of Health]. Harefuah. 2001 Nov;140(11):1062-7, 1117. Available from: PubMed; PMID 11759383 (Heb).
Dvorak R, Starling RD, Calles-Escandon J, Sims EA, Poehlman ET. Drug therapy for obesity in the elderly. Drugs Aging. 1997 Nov;11(5):338-51. Available from: PubMed; PMID 9359021
Edman JS, Williams WH, Atkins RC. Nutritional therapies for ulcerative colitis: literature review, chart review study, and future research. Altern Ther Health Med. 2000 Jan;6(1):55-63. Available from: PubMed; PMID 10631823
Ewies AA. A comprehensive approach to the menopause: so far, one size should fit all. Obstet Gynecol Surv. 2001 Oct;56(10):642-9. Available from: PubMed; PMID 11590315
Fano G, Mecocci P, Vecchiet J, Belia S, Fulle S, Polidori MC, Felzani G, Senin U, Vecchiet L, Beal MF. Age and sex influence on oxidative damage and functional status in human skeletal muscle. J Muscle Res Cell Motil. 2001;22(4):345-51. Available from: PubMed; PMID 11808774
Fenech M. Micronutrients and genomic stability: a new paradigm for recommended dietary allowances(RDAs). Food Chem Toxicol. 2002 Aug;40(8):1113-7. Available from: PubMed; PMID 12067572
Fenech M. Recommended dietary allowances(RDAs) for genomic stability. Mutat Res. 2001 Sep 1;480-481:51-4. Available from: PubMed; PMID 11506798
Ferrari E, Cravello L, Muzzoni B, Casarotti D, Paltro M, Solerte SB, Fioravanti M, Cuzzoni G, Pontiggia B, Magri F. Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates. Eur J Endocrinol. 2001 Apr;144(4):319-29. Available from: PubMed; PMID 11275940
Ferry M. [Vitamin and mineral deficiencies during aging]. Rev Geriatr. 1998;23(3):241-6. (Fre).
Fiatarone Singh MA, Bernstein MA, Ryan ND, O'Neill EF, Clements KM, Evans WJ. The effect of oral nutritional supplements on habitual dietary quality and quantity in frail elders. J Nutr Health Aging. 2000;4(1):5-12. Available from: PubMed; PMID 10828934
Fillit HM, Butler RN, O'Connell AW, Albert MS, Birren JE, Cotman CW, Greenough WT, Gold PE, Kramer AF, Kuller LH, Perls TT, Sahagan BG, Tully T. Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc. 2002 Jul;77(7):681-96. Available from: PubMed; PMID 12108606
Fillmore CM, Bartoli L, Bach R, Park Y. Nutrition and dietary supplements. Phys Med Rehabil Clin N Am. 1999 Aug;10(3):673-703. Available from: PubMed; PMID 10516985
Flanary B. The quest to extend life and overcome aging and death: Past, present, and future attempts. J Antiaging Med. 2002;5(2):161-72.
Forsyth LM, Preuss HG. Chronic fatigue syndrome and the elderly. Mature Med Can. 1999;2(3):141-3.
Franceschi S, Bidoli E, Negri E, Zambon P, Talamini R, Ruol A, Parpinel M, Levi F, Simonato L, La Vecchia C. Role of macronutrients, vitamins and minerals in the aetiology of squamous-cell carcinoma of the oesophagus. Int J Cancer. 2000 Jun 1;86(5):626-31. Available from: PubMed; PMID 10797282
Freng A, Daae LN, Engeland A, Norum KR, Sander J, Solvoll K, Tretli S. Malignant epithelial tumours in the upper digestive tract: a dietary and socio-medical case-control and survival study. Eur J Clin Nutr. 1998 Apr;52(4):271-8. Available from: PubMed; PMID 9578339
Fugh-Berman A, Cott JM. Dietary supplements and natural products as psychotherapeutic agents. Psychosom Med. 1999 Sep-Oct;61(5):712-28. Available from: PubMed; PMID 10511018
Fukagawa NK. Aging: is oxidative stress a marker or is it causal? Proc Soc Exp Biol Med. 1999 Dec;222(3):293-8. Available from: PubMed; PMID 10601888
Galan P, Preziosi P, Monget AL, Richard MJ, Arnaud J, Lesourd B, Girodon F, Alferez MJ, Bourgeois C, Keller H, Favier A, Hercberg S. Effects of trace element and/or vitamin supplementation on vitamin and mineral status, free radical metabolism and immunological markers in elderly long term-hospitalized subjects. Geriatric Network MIN. VIT. AOX. Int J Vitam Nutr Res. 1997;67(6):450-60. Available from: PubMed; PMID 9433680
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Hodes RJ. Meeting the challenges of an aging population. Acad Med. 1997 Oct;72(10):892-3. Available from: PubMed; PMID 9347711
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Hornick TR, Kowal J. Clinical epidemiology of endocrine disorders in the elderly. Endocrinol Metab Clin North Am. 1997 Mar;26(1):145-63. Available from: PubMed; PMID 9074857
Huffman GB. Evaluating and treating unintentional weight loss in the elderly. Am Fam Physician. 2002 Feb 15;65(4):640-50. Available from: PubMed; PMID 11871682
Ilich JZ, Kerstetter JE. Nutrition in bone health revisited: a story beyond calcium. J Am Coll Nutr. 2000 Nov-Dec;19(6):715-37. Available from: PubMed; PMID 11194525
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Jain AL. Influence of vitamins and trace-elements on the incidence of respiratory infection in the elderly. Nutr Res. 2002;22(1-2):85-7.
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Jonas WB. Researching alternative medicine. Nat Med. 1997 Aug;3(8):824-7. Available from: PubMed; PMID 9256264
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Koller W. [Effectiveness of combination preparations of calcium, vitamin D3, A and C with more beginning osteoporosis]. Erfahrunsheilkunde. 1997 Sep;46(9):537-40. (Ger).
Krauss RM, Eckel RH, Howard B, Appel LJ, Daniels SR, Deckelbaum RJ, Erdman JW Jr, Kris-Etherton P, Goldberg IJ, Kotchen TA, Lichtenstein AH, Mitch WE, Mullis R, Robinson K, Wylie-Rosett J, St Jeor S, Suttie J, Tribble DL, Bazzarre TL. AHA Dietary Guidelines Revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation. 2000 Oct 31;102(18):2284-99. Available from: PubMed; PMID 11056107
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